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C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65044, updated on 27-Nov-2024

Summary

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Official Symbol
C1galt1provided by RGD
Official Full Name
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1provided by RGD
Primary source
RGD:621105
See related
EnsemblRapid:ENSRNOG00000007804 AllianceGenome:RGD:621105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in kidney development. Predicted to act upstream of or within angiogenesis; intestinal epithelial cell development; and protein O-linked glycosylation. Predicted to be located in membrane. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 303.8), Liver (RPKM 263.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See C1galt1 in Genome Data Viewer
Location:
4q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (36894440..36932434)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (35930981..35966100)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (33890353..33943219)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene asparagine synthetase (glutamine-hydrolyzing) Neighboring gene uncharacterized LOC134486668 Neighboring gene tRNA (guanine-N(7)-)-methyltransferase-like Neighboring gene RNA polymerase I and III subunit D, pseudogene 1 Neighboring gene small nucleolar RNA SNORA3/SNORA45 family Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Variants of C1GALT1 gene are associated with the genetic susceptibility to IgA nephropathy. Li GS, et al. Kidney Int, 2007 Mar. PMID 17228361
  2. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. Fu J, et al. J Clin Invest, 2011 Apr. PMID 21383503, Free PMC Article
  3. Cloning and expression of human core 1 beta1,3-galactosyltransferase. Ju T, et al. J Biol Chem, 2002 Jan 4. PMID 11677243
  4. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. Xia L, et al. J Cell Biol, 2004 Feb 2. PMID 14745002, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal epithelial cell development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in kidney development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Names
core 1 O-glycan T-synthase
core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
core 1 beta1,3-galactosyltransferase 1
core 1 beta3-Gal-T
core 1 beta3-Gal-T1
core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase (C1galt1)
core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 13-galactosyltransferase (C1galt1)
NP_001385639.1
NP_075239.1
XP_063142739.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398710.1 → NP_001385639.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8L2Q5I0
    Related
    ENSRNOP00000010375.2, ENSRNOT00000010375.4
    Conserved Domains (1) summary
    cl21608
    Location:115 → 256
    Galactosyl_T; Galactosyltransferase

  2. NM_022950.3 → NP_075239.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_075239.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q9JJ05
    UniProtKB/TrEMBL
    A6IDW5
    Conserved Domains (1) summary
    cl21608
    Location:107 → 248
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    36894440..36932434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286669.1 → XP_063142739.1  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZNI5
    Related
    ENSRNOP00000079450.1, ENSRNOT00000112848.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJ05.1 GenPept UniProtKB/Swiss-Prot:Q9JJ05

Gene LinkOut

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