WNK1 WNK lysine deficient protein kinase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WNK1provided by HGNC
Official Full Name: WNK lysine deficient protein kinase 1provided by HGNC
Primary source: HGNC:HGNC:14540
See related: Ensembl:ENSG00000060237 MIM:605232; AllianceGenome:HGNC:14540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Expression: Ubiquitous expression in kidney (RPKM 30.2), fat (RPKM 24.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.33

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (752579..911452)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (748443..907208)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (861745..1020618)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
Title: WNK1 Interaction with KEAP1 Promotes NRF2 Stabilization to Enhance the Oxidative Stress Response in Hepatocellular Carcinoma.
The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
Title: The CREB1/WNK1 axis promotes the tumorigenesis of ovarian cancer via regulating HIF-1.
Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.
Title: Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.
A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.
Title: A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1.
WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.
Title: WNK1 mediates amphiregulin-induced MMP9 expression and cell invasion in human extravillous trophoblast cells.
WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.
Title: WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly.
Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.
Title: Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma.
Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway.
Title: Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway.
WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3beta-LHX8 pathway.
Title: WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway.
WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.
Title: WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.

Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neuropathy, hereditary sensory and autonomic, type 2A MedGen: C2752089 OMIM: 201300 GeneReviews: Hereditary Sensory and Autonomic Neuropathy Type II	Compare labs
Pseudohypoaldosteronism type 2C MedGen: C1840391 OMIM: 614492 GeneReviews: Pseudohypoaldosteronism Type II	Compare labs
Pseudohypoaldosteronism, type 2 MedGen: C1449844 GeneReviews: Pseudohypoaldosteronism Type II	Compare labs

EBI GWAS Catalog

Description
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC34797 (e-PCR)
- UniSTS:4

AFM206ze5 (e-PCR), detects polymorphism
- UniSTS:4881

G41780 (e-PCR)
- UniSTS:24858

A009W04 (e-PCR)
- UniSTS:57375

RH68501 (e-PCR)
- UniSTS:24623

G42615 (e-PCR)
- UniSTS:94515

SGC33532 (e-PCR)
- UniSTS:78389

RH78846 (e-PCR)
- UniSTS:49209

SHGC-36515 (e-PCR)
- UniSTS:29512

D12S1913 (e-PCR)
- UniSTS:51026

G41230 (e-PCR)
- UniSTS:58195

RH80475 (e-PCR)
- UniSTS:84056

D12S94 (e-PCR)
- UniSTS:15711

G41789 (e-PCR)
- UniSTS:25187

D12S2148 (e-PCR)
- UniSTS:58476

STS-N22269 (e-PCR)
- UniSTS:59247

SHGC-70148 (e-PCR)
- UniSTS:182650

RH11028 (e-PCR)
- UniSTS:88195

D12S1397 (e-PCR)
- UniSTS:4755

D12S888 (e-PCR)
- UniSTS:149918

D12S91 (e-PCR), detects polymorphism
- UniSTS:77729

G41016 (e-PCR)
- UniSTS:15014

NoName (e-PCR)
- UniSTS:487339

NoName (e-PCR)
- UniSTS:495281

G32902 (e-PCR)
- UniSTS:117481

D12S91 (e-PCR), detects polymorphism
- UniSTS:37354

G41015 (e-PCR)
- UniSTS:81142

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell volume homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to chemokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemokine (C-C motif) ligand 21 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in intracellular chloride ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in lymphocyte migration into lymph node	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in membraneless organelle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pancreatic juice secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron development	NAS Non-traceable Author Statement more info	PubMed
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-threonine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in peptidyl-threonine phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of termination of RNA polymerase II transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of regulation of monoatomic cation transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membraneless organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase WNK1

Names: erythrocyte 65 kDa protein; prostate-derived sterile 20-like kinase; protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2

NP_001171914.1

EC 2.7.11.1

NP_055638.2

EC 2.7.11.1

NP_061852.3

EC 2.7.11.1

NP_998820.3

EC 2.7.11.1

XP_006719066.1

EC 2.7.11.1

XP_011519299.1

EC 2.7.11.1

XP_011519300.1

EC 2.7.11.1

XP_011519301.1

EC 2.7.11.1

XP_011519302.1

EC 2.7.11.1

XP_011519303.1

EC 2.7.11.1

XP_011519304.1

EC 2.7.11.1

XP_011519305.1

EC 2.7.11.1

XP_011519308.1

EC 2.7.11.1

XP_011519309.1

EC 2.7.11.1

XP_011519310.1

EC 2.7.11.1

XP_011519311.1

EC 2.7.11.1

XP_016875323.1

EC 2.7.11.1

XP_016875324.1

EC 2.7.11.1

XP_016875325.1

EC 2.7.11.1

XP_016875326.1

EC 2.7.11.1

XP_016875327.1

EC 2.7.11.1

XP_047285330.1

EC 2.7.11.1

XP_047285331.1

EC 2.7.11.1

XP_047285332.1

EC 2.7.11.1

XP_047285333.1

EC 2.7.11.1

XP_047285334.1

EC 2.7.11.1

XP_047285335.1

EC 2.7.11.1

XP_047285336.1

EC 2.7.11.1

XP_047285337.1

EC 2.7.11.1

XP_047285338.1

EC 2.7.11.1

XP_047285339.1

EC 2.7.11.1

XP_047285340.1

EC 2.7.11.1

XP_047285341.1

EC 2.7.11.1

XP_047285342.1

EC 2.7.11.1

XP_047285343.1

EC 2.7.11.1

XP_047285344.1

EC 2.7.11.1

XP_047285345.1

EC 2.7.11.1

XP_047285346.1

EC 2.7.11.1

XP_047285347.1

EC 2.7.11.1

XP_047285348.1

EC 2.7.11.1

XP_047285349.1

EC 2.7.11.1

XP_047285350.1

EC 2.7.11.1

XP_047285351.1

EC 2.7.11.1

XP_047285352.1

EC 2.7.11.1

XP_047285353.1

EC 2.7.11.1

XP_047285354.1

EC 2.7.11.1

XP_047285355.1

EC 2.7.11.1

XP_047285356.1

EC 2.7.11.1

XP_047285357.1

EC 2.7.11.1

XP_047285358.1

EC 2.7.11.1

XP_047285359.1

EC 2.7.11.1

XP_054228909.1

EC 2.7.11.1

XP_054228910.1

EC 2.7.11.1

XP_054228911.1

EC 2.7.11.1

XP_054228912.1

EC 2.7.11.1

XP_054228913.1

EC 2.7.11.1

XP_054228914.1

EC 2.7.11.1

XP_054228915.1

EC 2.7.11.1

XP_054228916.1

EC 2.7.11.1

XP_054228917.1

EC 2.7.11.1

XP_054228918.1

EC 2.7.11.1

XP_054228919.1

EC 2.7.11.1

XP_054228920.1

EC 2.7.11.1

XP_054228921.1

EC 2.7.11.1

XP_054228922.1

EC 2.7.11.1

XP_054228923.1

EC 2.7.11.1

XP_054228924.1

EC 2.7.11.1

XP_054228925.1

EC 2.7.11.1

XP_054228926.1

EC 2.7.11.1

XP_054228927.1

EC 2.7.11.1

XP_054228928.1

EC 2.7.11.1

XP_054228929.1

EC 2.7.11.1

XP_054228930.1

EC 2.7.11.1

XP_054228931.1

EC 2.7.11.1

XP_054228932.1

EC 2.7.11.1

XP_054228933.1

EC 2.7.11.1

XP_054228934.1

EC 2.7.11.1

XP_054228935.1

EC 2.7.11.1

XP_054228936.1

EC 2.7.11.1

XP_054228937.1

EC 2.7.11.1

XP_054228938.1

EC 2.7.11.1

XP_054228939.1

EC 2.7.11.1

XP_054228940.1

EC 2.7.11.1

XP_054228941.1

EC 2.7.11.1

XP_054228942.1

EC 2.7.11.1

XP_054228943.1

EC 2.7.11.1

XP_054228944.1

EC 2.7.11.1

XP_054228945.1

EC 2.7.11.1

XP_054228946.1

EC 2.7.11.1

XP_054228947.1

EC 2.7.11.1

XP_054228948.1

EC 2.7.11.1

XP_054228949.1

EC 2.7.11.1

XP_054228950.1

EC 2.7.11.1

XP_054228951.1

EC 2.7.11.1

XP_054228952.1

EC 2.7.11.1

XP_054228953.1

EC 2.7.11.1

XP_054228954.1

EC 2.7.11.1

XP_054228955.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007984.3 RefSeqGene

Range

4521..163394

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_247

mRNA and Protein(s)

NM_001184985.2 → NP_001171914.1 serine/threonine-protein kinase WNK1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is longer than isoform 1.

Source sequence(s)

AC004765, AC004803

UniProtKB/Swiss-Prot

Q9H4A3

Related

ENSP00000444465.1, ENST00000537687.5

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_014823.3 → NP_055638.2 serine/threonine-protein kinase WNK1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses two alternative splice sites and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959

Consensus CDS

CCDS53731.1

UniProtKB/TrEMBL

F5GWT4

Related

ENSP00000441972.1, ENST00000535572.5

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_018979.4 → NP_061852.3 serine/threonine-protein kinase WNK1 isoform 1

See identical proteins and their annotated locations for NP_061852.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the most common isoform (1), as indicated in PubMed ID 18521183.

Source sequence(s)

AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959

Consensus CDS

CCDS8506.1

UniProtKB/Swiss-Prot

A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673, Q96CZ6, Q9H4A3, Q9P1S9

Related

ENSP00000313059.6, ENST00000315939.11

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
NM_213655.5 → NP_998820.3 serine/threonine-protein kinase WNK1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 3, which is longer than isoform 1.

Source sequence(s)

AC004765, AC004803

Consensus CDS

CCDS73419.1

UniProtKB/Swiss-Prot

Q9H4A3

Related

ENSP00000341292.5, ENST00000340908.9

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

752579..911452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011520997.4 → XP_011519299.1 serine/threonine-protein kinase WNK1 isoform X1

Related

ENSP00000433548.3, ENST00000530271.6

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_011521000.3 → XP_011519302.1 serine/threonine-protein kinase WNK1 isoform X4

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_011520999.3 → XP_011519301.1 serine/threonine-protein kinase WNK1 isoform X3

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429374.1 → XP_047285330.1 serine/threonine-protein kinase WNK1 isoform X5
XM_011521001.3 → XP_011519303.1 serine/threonine-protein kinase WNK1 isoform X6

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429375.1 → XP_047285331.1 serine/threonine-protein kinase WNK1 isoform X7
XM_047429376.1 → XP_047285332.1 serine/threonine-protein kinase WNK1 isoform X9
XM_011521003.3 → XP_011519305.1 serine/threonine-protein kinase WNK1 isoform X10

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_011520998.3 → XP_011519300.1 serine/threonine-protein kinase WNK1 isoform X2

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_011521002.3 → XP_011519304.1 serine/threonine-protein kinase WNK1 isoform X8

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429377.1 → XP_047285333.1 serine/threonine-protein kinase WNK1 isoform X12
XM_047429380.1 → XP_047285336.1 serine/threonine-protein kinase WNK1 isoform X17
XM_047429383.1 → XP_047285339.1 serine/threonine-protein kinase WNK1 isoform X20
XM_047429388.1 → XP_047285344.1 serine/threonine-protein kinase WNK1 isoform X25
XM_047429393.1 → XP_047285349.1 serine/threonine-protein kinase WNK1 isoform X33
XM_047429389.1 → XP_047285345.1 serine/threonine-protein kinase WNK1 isoform X27
XM_017019837.2 → XP_016875326.1 serine/threonine-protein kinase WNK1 isoform X34

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429400.1 → XP_047285356.1 serine/threonine-protein kinase WNK1 isoform X44
XM_047429395.1 → XP_047285351.1 serine/threonine-protein kinase WNK1 isoform X37
XM_006719003.3 → XP_006719066.1 serine/threonine-protein kinase WNK1 isoform X11

Conserved Domains (2) summary

PHA03247
Location:1572 → 1866

PHA03247; large tegument protein UL36; Provisional

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
XM_047429378.1 → XP_047285334.1 serine/threonine-protein kinase WNK1 isoform X13
XM_047429382.1 → XP_047285338.1 serine/threonine-protein kinase WNK1 isoform X19
XM_047429384.1 → XP_047285340.1 serine/threonine-protein kinase WNK1 isoform X21
XM_017019834.2 → XP_016875323.1 serine/threonine-protein kinase WNK1 isoform X26
XM_047429390.1 → XP_047285346.1 serine/threonine-protein kinase WNK1 isoform X28
XM_017019838.2 → XP_016875327.1 serine/threonine-protein kinase WNK1 isoform X36
XM_047429401.1 → XP_047285357.1 serine/threonine-protein kinase WNK1 isoform X45
XM_047429402.1 → XP_047285358.1 serine/threonine-protein kinase WNK1 isoform X46
XM_011521006.3 → XP_011519308.1 serine/threonine-protein kinase WNK1 isoform X14

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429381.1 → XP_047285337.1 serine/threonine-protein kinase WNK1 isoform X18
XM_047429379.1 → XP_047285335.1 serine/threonine-protein kinase WNK1 isoform X16
XM_047429385.1 → XP_047285341.1 serine/threonine-protein kinase WNK1 isoform X22
XM_017019835.2 → XP_016875324.1 serine/threonine-protein kinase WNK1 isoform X29
XM_047429394.1 → XP_047285350.1 serine/threonine-protein kinase WNK1 isoform X35
XM_047429391.1 → XP_047285347.1 serine/threonine-protein kinase WNK1 isoform X31
XM_047429397.1 → XP_047285353.1 serine/threonine-protein kinase WNK1 isoform X39
XM_011521008.3 → XP_011519310.1 serine/threonine-protein kinase WNK1 isoform X40

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429398.1 → XP_047285354.1 serine/threonine-protein kinase WNK1 isoform X42
XM_011521007.3 → XP_011519309.1 serine/threonine-protein kinase WNK1 isoform X15

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429386.1 → XP_047285342.1 serine/threonine-protein kinase WNK1 isoform X23
XM_047429387.1 → XP_047285343.1 serine/threonine-protein kinase WNK1 isoform X24
XM_017019836.2 → XP_016875325.1 serine/threonine-protein kinase WNK1 isoform X30
XM_047429396.1 → XP_047285352.1 serine/threonine-protein kinase WNK1 isoform X38
XM_047429392.1 → XP_047285348.1 serine/threonine-protein kinase WNK1 isoform X32
XM_011521009.3 → XP_011519311.1 serine/threonine-protein kinase WNK1 isoform X41

Conserved Domains (3) summary

smart00220
Location:226 → 479

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14030
Location:195 → 483

STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1

pfam12202
Location:500 → 537

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
XM_047429399.1 → XP_047285355.1 serine/threonine-protein kinase WNK1 isoform X43
XM_047429403.1 → XP_047285359.1 serine/threonine-protein kinase WNK1 isoform X47

Related

ENSP00000502415.1, ENST00000675631.1

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

748443..907208

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372934.1 → XP_054228909.1 serine/threonine-protein kinase WNK1 isoform X1
XM_054372937.1 → XP_054228912.1 serine/threonine-protein kinase WNK1 isoform X4
XM_054372936.1 → XP_054228911.1 serine/threonine-protein kinase WNK1 isoform X3
XM_054372938.1 → XP_054228913.1 serine/threonine-protein kinase WNK1 isoform X5
XM_054372939.1 → XP_054228914.1 serine/threonine-protein kinase WNK1 isoform X6
XM_054372940.1 → XP_054228915.1 serine/threonine-protein kinase WNK1 isoform X7
XM_054372942.1 → XP_054228917.1 serine/threonine-protein kinase WNK1 isoform X9
XM_054372943.1 → XP_054228918.1 serine/threonine-protein kinase WNK1 isoform X10
XM_054372935.1 → XP_054228910.1 serine/threonine-protein kinase WNK1 isoform X2
XM_054372941.1 → XP_054228916.1 serine/threonine-protein kinase WNK1 isoform X8
XM_054372945.1 → XP_054228920.1 serine/threonine-protein kinase WNK1 isoform X12
XM_054372950.1 → XP_054228925.1 serine/threonine-protein kinase WNK1 isoform X17
XM_054372953.1 → XP_054228928.1 serine/threonine-protein kinase WNK1 isoform X20
XM_054372958.1 → XP_054228933.1 serine/threonine-protein kinase WNK1 isoform X25
XM_054372966.1 → XP_054228941.1 serine/threonine-protein kinase WNK1 isoform X33
XM_054372960.1 → XP_054228935.1 serine/threonine-protein kinase WNK1 isoform X27
XM_054372967.1 → XP_054228942.1 serine/threonine-protein kinase WNK1 isoform X34
XM_054372977.1 → XP_054228952.1 serine/threonine-protein kinase WNK1 isoform X44
XM_054372970.1 → XP_054228945.1 serine/threonine-protein kinase WNK1 isoform X37
XM_054372944.1 → XP_054228919.1 serine/threonine-protein kinase WNK1 isoform X11
XM_054372946.1 → XP_054228921.1 serine/threonine-protein kinase WNK1 isoform X13
XM_054372952.1 → XP_054228927.1 serine/threonine-protein kinase WNK1 isoform X19
XM_054372954.1 → XP_054228929.1 serine/threonine-protein kinase WNK1 isoform X21
XM_054372959.1 → XP_054228934.1 serine/threonine-protein kinase WNK1 isoform X26
XM_054372961.1 → XP_054228936.1 serine/threonine-protein kinase WNK1 isoform X28
XM_054372969.1 → XP_054228944.1 serine/threonine-protein kinase WNK1 isoform X36
XM_054372978.1 → XP_054228953.1 serine/threonine-protein kinase WNK1 isoform X45
XM_054372979.1 → XP_054228954.1 serine/threonine-protein kinase WNK1 isoform X46
XM_054372947.1 → XP_054228922.1 serine/threonine-protein kinase WNK1 isoform X14
XM_054372951.1 → XP_054228926.1 serine/threonine-protein kinase WNK1 isoform X18
XM_054372949.1 → XP_054228924.1 serine/threonine-protein kinase WNK1 isoform X16
XM_054372955.1 → XP_054228930.1 serine/threonine-protein kinase WNK1 isoform X22
XM_054372962.1 → XP_054228937.1 serine/threonine-protein kinase WNK1 isoform X29
XM_054372968.1 → XP_054228943.1 serine/threonine-protein kinase WNK1 isoform X35
XM_054372964.1 → XP_054228939.1 serine/threonine-protein kinase WNK1 isoform X31
XM_054372972.1 → XP_054228947.1 serine/threonine-protein kinase WNK1 isoform X39
XM_054372973.1 → XP_054228948.1 serine/threonine-protein kinase WNK1 isoform X40
XM_054372975.1 → XP_054228950.1 serine/threonine-protein kinase WNK1 isoform X42
XM_054372948.1 → XP_054228923.1 serine/threonine-protein kinase WNK1 isoform X15
XM_054372956.1 → XP_054228931.1 serine/threonine-protein kinase WNK1 isoform X23
XM_054372957.1 → XP_054228932.1 serine/threonine-protein kinase WNK1 isoform X24
XM_054372963.1 → XP_054228938.1 serine/threonine-protein kinase WNK1 isoform X30
XM_054372971.1 → XP_054228946.1 serine/threonine-protein kinase WNK1 isoform X38
XM_054372965.1 → XP_054228940.1 serine/threonine-protein kinase WNK1 isoform X32
XM_054372974.1 → XP_054228949.1 serine/threonine-protein kinase WNK1 isoform X41
XM_054372976.1 → XP_054228951.1 serine/threonine-protein kinase WNK1 isoform X43
XM_054372980.1 → XP_054228955.1 serine/threonine-protein kinase WNK1 isoform X47