Dhodh dihydroorotate dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhodhprovided by RGD
Official Full Name: dihydroorotate dehydrogenaseprovided by RGD
Primary source: RGD:68352
See related: EnsemblRapid:ENSRNOG00000015063 AllianceGenome:RGD:68352
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables FMN binding activity; dihydroorotate dehydrogenase activity; and ubiquinone binding activity. Involved in several processes, including 'de novo' pyrimidine nucleobase biosynthetic process; lactation; and response to L-arginine. Located in mitochondrial inner membrane and neuronal cell body. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 46.5), Thymus (RPKM 40.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (54460636..54483049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (37551858..37573327, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (42066103..42087906)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High levels of both DHODH activity and immunoreactivity were observed in the neocortex, hippocampus, spinal cord and choroid plexus; lower levels were seen in the cerebellum, and only marginal expression in brainstem
Title: Region-specific distribution of dihydroorotate dehydrogenase in the rat central nervous system points to pyrimidine de novo synthesis in neurons.
Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells of different species
Title: Dihydroorotate dehydrogenase mRNA and protein expression analysis in normal and drug-resistant cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FMN binding	IDA Inferred from Direct Assay more info	PubMed
enables dihydroorotase activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotase activity	ISO Inferred from Sequence Orthology more info
enables dihydroorotate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables dihydroorotate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroorotate dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables dihydroorotate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables dihydroorotate dehydrogenase activity	NAS Non-traceable Author Statement more info	PubMed
enables quinone binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquinone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' UMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyrimidine ribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to L-arginine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to caffeine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dihydroorotate dehydrogenase (quinone), mitochondrial

Names: DHOdehase; dihydroorotate dehydrogenase, mitochondrial; dihydroorotate oxidase

NP_001008553.1

EC 1.3.5.2

XP_006255663.1

EC 1.3.5.2

XP_008770751.1

EC 1.3.5.2

XP_063134344.1

EC 1.3.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008553.2 → NP_001008553.1 dihydroorotate dehydrogenase (quinone), mitochondrial precursor

See identical proteins and their annotated locations for NP_001008553.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q63707

UniProtKB/TrEMBL

A0A8I6APC4

Related

ENSRNOP00000091052.2, ENSRNOT00000102191.2

Conserved Domains (2) summary

PLN02826
Location:4 → 394

PLN02826; dihydroorotate dehydrogenase

cd04738
Location:43 → 373

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

54460636..54483049 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255601.5 → XP_006255663.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

See identical proteins and their annotated locations for XP_006255663.1

UniProtKB/Swiss-Prot

Q63707

UniProtKB/TrEMBL

A0A8I6APC4

Conserved Domains (2) summary

PLN02826
Location:4 → 394

PLN02826; dihydroorotate dehydrogenase

cd04738
Location:43 → 373

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...
XM_063278274.1 → XP_063134344.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q63707
XM_008772529.4 → XP_008770751.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

See identical proteins and their annotated locations for XP_008770751.1

UniProtKB/Swiss-Prot

Q63707

UniProtKB/TrEMBL

A0A8I6APC4

Conserved Domains (2) summary

PLN02826
Location:4 → 394

PLN02826; dihydroorotate dehydrogenase

cd04738
Location:43 → 373

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...