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rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Danio rerio (zebrafish) ]

Gene ID: 65227, updated on 4-Jan-2025

Summary

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Official Symbol
rgl2provided by ZNC
Official Full Name
ral guanine nucleotide dissociation stimulator-like 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010131-1
See related
Ensembl:ENSDARG00000007727 AllianceGenome:ZFIN:ZDB-GENE-010131-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rab2l; im:7136742
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See rgl2 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (45358955..45417216, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (45397663..45450694, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33i11.1 Neighboring gene uncharacterized LOC137487976 Neighboring gene deoxyribonuclease II, lysosomal Neighboring gene synaptic Ras GTPase activating protein 1b Neighboring gene PHD finger protein 1 Neighboring gene SMG5 nonsense mediated mRNA decay factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary history of the ABCB2 genomic region in teleosts. Palti Y, et al. Dev Comp Immunol, 2007. PMID 17055577
  2. Conservation of Mhc class III region synteny between zebrafish and human as determined by radiation hybrid mapping. Sültmann H, et al. J Immunol, 2000 Dec 15. PMID 11120825
  3. Dissecting the roles of Raf- and PI3K-signalling pathways in melanoma formation and progression in a zebrafish model. Michailidou C, et al. Dis Model Mech, 2009 Jul-Aug. PMID 19470611
  4. Identification of vasculature-specific genes by microarray analysis of Etsrp/Etv2 overexpressing zebrafish embryos. Wong KS, et al. Dev Dyn, 2009 Jul. PMID 19504456
  5. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
ras-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115093.2 → NP_001108565.2  ral guanine nucleotide dissociation stimulator-like 2

    See identical proteins and their annotated locations for NP_001108565.2

    Status: PROVISIONAL

    Source sequence(s)
    BC162718
    UniProtKB/TrEMBL
    B3DHC8
    Related
    ENSDARP00000025191.7, ENSDART00000004052.8
    Conserved Domains (3) summary
    cd06224
    Location:89 → 168
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:234 → 497
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl00155
    Location:604 → 688
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    45358955..45417216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158384.5 → XP_005158441.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    See identical proteins and their annotated locations for XP_005158441.1

    UniProtKB/TrEMBL
    A0A8M2B5A7
    Conserved Domains (3) summary
    cd06224
    Location:111 → 190
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:256 → 519
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl00155
    Location:626 → 710
    UBQ; Ubiquitin-like proteins

  2. XM_017351361.3 → XP_017206850.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5A7
    Conserved Domains (3) summary
    cd06224
    Location:111 → 190
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    smart00147
    Location:256 → 519
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cl00155
    Location:626 → 710
    UBQ; Ubiquitin-like proteins

  3. XM_068214008.1 → XP_068070109.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5A7
Nucleotide Protein Strain
Heading Accession and Version

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