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Asb1 ankyrin repeat and SOCS box-containing 1 [ Mus musculus (house mouse) ]

Gene ID: 65247, updated on 27-Nov-2024

Summary

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Official Symbol
Asb1provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 1provided by MGI
Primary source
MGI:MGI:1929735
See related
Ensembl:ENSMUSG00000026311 AllianceGenome:MGI:1929735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1146; 1700029O08Rik; 1700054C17Rik
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 17.6), liver E14 (RPKM 5.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Asb1 in Genome Data Viewer
Location:
1 D; 1 46.19 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91467725..91487312)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91540001..91559590)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene nucleolar complex associated 3 homolog pseudogene Neighboring gene TRAF3 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_01698 Neighboring gene STARR-positive B cell enhancer ABC_E1555 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93497438-93497621 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93498155-93498356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93527619-93527999 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93529086-93529287 Neighboring gene predicted gene 28380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93547237-93547420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93555659-93555944 Neighboring gene STARR-seq mESC enhancer starr_01699 Neighboring gene STARR-seq mESC enhancer starr_01700 Neighboring gene twist basic helix-loop-helix transcription factor 2 Neighboring gene predicted gene, 46117

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis. Hou P, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33431678, Free PMC Article
  2. Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model. Emeny RT, et al. Neuropsychopharmacology, 2018 Jan. PMID 28540928, Free PMC Article
  3. Two new behavioral QTLs, Emo4 and Reb1, map to mouse Chromosome 1: Congenic strains and candidate gene identification studies. de Ledesma AM, et al. Mamm Genome, 2006 Feb. PMID 16465591
  4. Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4. Kile BT, et al. Gene, 2000 Nov 27. PMID 11111040
  5. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An unconventional role of an ASB family protein in NF-kappaB activation and inflammatory response during microbial infection and colitis.
    Title: An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis.
  2. In murine acute social defeat stress, Asb1 gene expression is significantly upregulated in a tissue-specific manner (p=0.006), which correlates with upregulation of the neuroimmunomodulating cytokine interleukin 1 beta.
    Title: Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 1
Names
ASB-1
ankyrin repeat and SOCS box-containing protein 1
ankyrin repeat-containing SOCS box protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039126.2 → NP_001034215.1  ankyrin repeat and SOCS box protein 1 isoform a

    See identical proteins and their annotated locations for NP_001034215.1

    Status: VALIDATED

    Source sequence(s)
    AC109199, AK153774, BY231875
    Consensus CDS
    CCDS35665.1
    UniProtKB/Swiss-Prot
    Q9WV74
    UniProtKB/TrEMBL
    Q3U5A0, Q80TI9
    Related
    ENSMUSP00000084054.6, ENSMUST00000086843.11
    Conserved Domains (5) summary
    cd00204
    Location:80 → 213
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:295 → 336
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:83 → 174
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:40 → 99
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:80 → 109
    ANK; ANK repeat [structural motif]

  2. NM_023046.4 → NP_075533.3  ankyrin repeat and SOCS box protein 1 isoform b

    See identical proteins and their annotated locations for NP_075533.3

    Status: VALIDATED

    Source sequence(s)
    AC109199, AK153774, BU938650
    Consensus CDS
    CCDS35666.1
    UniProtKB/TrEMBL
    G3X9J5, Q9D9S9
    Related
    ENSMUSP00000140731.2, ENSMUST00000188879.2
    Conserved Domains (5) summary
    cd00204
    Location:72 → 205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:287 → 328
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:75 → 166
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:32 → 91
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:72 → 101
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91467725..91487312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529790.5 → XP_006529853.1  ankyrin repeat and SOCS box protein 1 isoform X2

    UniProtKB/TrEMBL
    S4W6L8
    Related
    ENSMUSP00000140281.2, ENSMUST00000190484.7
    Conserved Domains (3) summary
    COG0666
    Location:21 → 164
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd03720
    Location:194 → 235
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:39 → 72
    ANK; ANK repeat [structural motif]

  2. XM_006529789.3 → XP_006529852.1  ankyrin repeat and SOCS box protein 1 isoform X1

    UniProtKB/TrEMBL
    Q9D9S9
    Conserved Domains (5) summary
    PHA02875
    Location:77 → 263
    PHA02875; ankyrin repeat protein; Provisional
    cd03720
    Location:291 → 332
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:76 → 105
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:79 → 170
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:19 → 105
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV74.1 GenPept UniProtKB/Swiss-Prot:Q9WV74

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