U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZDHHC11B zinc finger DHHC-type containing 11B [ Homo sapiens (human) ]

Gene ID: 653082, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZDHHC11Bprovided by HGNC
Official Full Name
zinc finger DHHC-type containing 11Bprovided by HGNC
Primary source
HGNC:HGNC:32962
See related
Ensembl:ENSG00000206077 AllianceGenome:HGNC:32962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC-11B
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in several processes, including antiviral innate immune response; peptidyl-L-cysteine S-palmitoylation; and positive regulation of defense response to virus by host. Predicted to be located in endosome membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung (RPKM 4.3), brain (RPKM 3.1) and 23 other tissues See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZDHHC11B in Genome Data Viewer
Location:
5p15.33
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (710355..784729, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (710470..784844, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:612309-613238 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:618691-619890 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86736 Neighboring gene centrosomal protein 72 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643172-643672 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86741 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:643673-644173 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86745 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86749/86750 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86753 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86779 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86783 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:669166-669920 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86803 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:673521-674090 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86819 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_86823 and experimental_86827 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86831 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86841/86842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:686929-687430 Neighboring gene tubulin polymerization promoting protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:692893-693475 Neighboring gene uncharacterized LOC101929898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene zinc finger DHHC-type containing 11 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene bromodomain containing 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition. Dai H, et al. Cancer Med, 2023 Aug. PMID 37434393, Free PMC Article
  2. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Dzikiewicz-Krawczyk A, et al. Leukemia, 2017 Jun. PMID 28331227
  3. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Zhang H, et al. Nucleic Acids Res, 2019 Nov 4. PMID 31495888, Free PMC Article
  4. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition.
    Title: ZDHHC11B is decreased in lung adenocarcinoma and inhibits tumorigenesis via regulating epithelial-mesenchymal transition.
  2. First, MYC downregulates miR-150 to unleash MYB from the miR-150-mediated repression. Second, MYC induces ZDHHC11 and ZDHHC11B that further ensures the maintenance of high MYB levels
    Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable palmitoyltransferase ZDHHC11B
Names
zinc finger DHHC domain-containing protein 11B
NP_001338232.1
XP_016865599.1
XP_016865600.1
XP_016865601.1
XP_016865602.1
XP_016865603.1
XP_016865604.1
XP_016865605.1
XP_016865606.1
XP_016865607.1
XP_016865608.1
XP_016865610.1
XP_024301956.1
XP_047273536.1
XP_047273538.1
XP_047273539.1
XP_047273540.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351303.2 → NP_001338232.1  probable palmitoyltransferase ZDHHC11B

    Status: VALIDATED

    Source sequence(s)
    AC026740
    Consensus CDS
    CCDS87287.1
    UniProtKB/Swiss-Prot
    A6NHR3, P0C7U3
    Related
    ENSP00000442373.2, ENST00000508859.8
    Conserved Domains (2) summary
    pfam01529
    Location:120 → 274
    zf-DHHC; DHHC palmitoyltransferase
    cl19890
    Location:38 → 190
    zf-DHHC; DHHC palmitoyltransferase

RNA

  1. NR_147095.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026740

  2. NR_147096.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026740

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    710355..784729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010111.2 → XP_016865600.1  probable palmitoyltransferase ZDHHC11B isoform X1

  2. XM_017010110.2 → XP_016865599.1  probable palmitoyltransferase ZDHHC11B isoform X1

  3. XM_017010115.3 → XP_016865604.1  probable palmitoyltransferase ZDHHC11B isoform X1

  4. XM_017010113.3 → XP_016865602.1  probable palmitoyltransferase ZDHHC11B isoform X1

  5. XM_017010114.3 → XP_016865603.1  probable palmitoyltransferase ZDHHC11B isoform X1

  6. XM_017010112.2 → XP_016865601.1  probable palmitoyltransferase ZDHHC11B isoform X1

  7. XM_017010117.2 → XP_016865606.1  probable palmitoyltransferase ZDHHC11B isoform X4

  8. XM_017010116.3 → XP_016865605.1  probable palmitoyltransferase ZDHHC11B isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 329
    zf-DHHC; DHHC palmitoyltransferase

  9. XM_047417580.1 → XP_047273536.1  probable palmitoyltransferase ZDHHC11B isoform X2

  10. XM_024446188.1 → XP_024301956.1  probable palmitoyltransferase ZDHHC11B isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:193 → 329
    zf-DHHC; DHHC palmitoyltransferase

  11. XM_017010118.1 → XP_016865607.1  probable palmitoyltransferase ZDHHC11B isoform X5

  12. XM_017010119.1 → XP_016865608.1  probable palmitoyltransferase ZDHHC11B isoform X6

  13. XM_047417582.1 → XP_047273538.1  probable palmitoyltransferase ZDHHC11B isoform X8

  14. XM_017010121.1 → XP_016865610.1  probable palmitoyltransferase ZDHHC11B isoform X7

    Conserved Domains (1) summary
    cl19890
    Location:193 → 265
    zf-DHHC; DHHC palmitoyltransferase

  15. XM_047417584.1 → XP_047273540.1  probable palmitoyltransferase ZDHHC11B isoform X10

  16. XM_047417583.1 → XP_047273539.1  probable palmitoyltransferase ZDHHC11B isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7U3.1 GenPept UniProtKB/Swiss-Prot:P0C7U3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools