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ZNF732 zinc finger protein 732 [ Homo sapiens (human) ]

Gene ID: 654254, updated on 27-Nov-2024

Summary

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Official Symbol
ZNF732provided by HGNC
Official Full Name
zinc finger protein 732provided by HGNC
Primary source
HGNC:HGNC:37138
See related
Ensembl:ENSG00000186777 AllianceGenome:HGNC:37138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and sixteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Expression
Broad expression in testis (RPKM 1.2), lymph node (RPKM 0.4) and 20 other tissues See more
Orthologs
all
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Genomic context

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See ZNF732 in Genome Data Viewer
Location:
4p16.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (270675..305474, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (264018..298819, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (264464..299263, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 141-like Neighboring gene zinc finger protein 876, pseudogene Neighboring gene endogenous retrovirus group FRD member 1, envelope pseudogene Neighboring gene uncharacterized LOC105374336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15096 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15097 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:330727-331242 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:331348-332308 Neighboring gene zinc finger protein 141 Neighboring gene microRNA 571

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Imbeault M, et al. Nature, 2017 Mar 23. PMID 28273063
  2. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. Wang W, et al. PLoS One, 2014. PMID 24647005, Free PMC Article
  3. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
  4. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940
  5. Genome-wide association study of antibody response to smallpox vaccine. Ovsyannikova IG, et al. Vaccine, 2012 Jun 13. PMID 22542470, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ59067

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 732
Names
zinc finger protein LOC654254

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137608.3 → NP_001131080.1  zinc finger protein 732

    See identical proteins and their annotated locations for NP_001131080.1

    Status: VALIDATED

    Source sequence(s)
    AC079140, AK302099, HY033234
    Consensus CDS
    CCDS46990.1
    UniProtKB/Swiss-Prot
    B4DXR9
    Related
    ENSP00000415774.1, ENST00000419098.6
    Conserved Domains (5) summary
    smart00349
    Location:4 → 62
    KRAB; krueppel associated box
    COG5048
    Location:130 → 542
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:308 → 328
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:349 → 373
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    270675..305474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    264018..298819 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B4DXR9.1 GenPept UniProtKB/Swiss-Prot:B4DXR9

Gene LinkOut

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