Fkbp11 FK506 binding protein 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fkbp11provided by MGI
Official Full Name: FK506 binding protein 11provided by MGI
Primary source: MGI:MGI:1913370
See related: Ensembl:ENSMUSG00000003355 AllianceGenome:MGI:1913370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FKBP-11; 1110002O23Rik
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including craniocervical region bone; incisor; liver lobe; pancreas tip epithelium; and thoracic segment skeleton. Orthologous to human FKBP11 (FKBP prolyl isomerase 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E18 (RPKM 54.8), liver E14.5 (RPKM 27.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98622249..98626079, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98724368..98728198, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diabesity? No worries, FKBP11 to the rescue.
Title: Diabesity? No worries, FKBP11 to the rescue.
FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity.
Title: FKBP11 rewires UPR signaling to promote glucose homeostasis in type 2 diabetes and obesity.
these results suggest that the UPR protein FKBP11 may protect IECs against IFNg/TNFa induced apoptosis by inhibiting the ER stressassociated JNK/caspase apoptotic pathway in Crohn's disease
Title: FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease.
These results indicate that the S-palmitoylation on IFITM5 promotes the interaction with FKBP11.
Title: Role of S-palmitoylation on IFITM5 for the interaction with FKBP11 in osteoblast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone-mediated protein folding	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase FKBP11

Names: 19 kDa FK506-binding protein; 19 kDa FKBP; FKBP-19; PPIase FKBP11; rotamase

NP_001344822.1

EC 5.2.1.8

NP_077131.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357893.1 → NP_001344822.1 peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC156543

Conserved Domains (1) summary

pfam00254
Location:3 → 79

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
NM_024169.4 → NP_077131.2 peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

See identical proteins and their annotated locations for NP_077131.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC156543, AK003331

Consensus CDS

CCDS27803.1

UniProtKB/Swiss-Prot

Q9CRE4, Q9D1M7

Related

ENSMUSP00000003445.7, ENSMUST00000003445.8

Conserved Domains (1) summary

pfam00254
Location:50 → 141

FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase