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Maco1 macoilin 1 [ Mus musculus (house mouse) ]

Gene ID: 66146, updated on 27-Nov-2024

Summary

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Official Symbol
Maco1provided by MGI
Official Full Name
macoilin 1provided by MGI
Primary source
MGI:MGI:1913396
See related
Ensembl:ENSMUSG00000028826 AllianceGenome:MGI:1913396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C61; Tmem57; 1110007C24Rik; 9230118A01Rik
Summary
Predicted to enable microtubule binding activity. Involved in brain development. Located in several cellular components, including axon; neuron projection terminus; and nuclear membrane. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; cortical plate; and testis. Orthologous to human MACO1 (macoilin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 14.9), CNS E18 (RPKM 14.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Maco1 in Genome Data Viewer
Location:
4 D3; 4 67.11 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134530070..134581242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134802759..134853931, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene mannosidase, alpha, class 1C, member 1 Neighboring gene predicted gene, 42326 Neighboring gene STARR-seq mESC enhancer starr_11682 Neighboring gene STARR-seq mESC enhancer starr_11683 Neighboring gene STARR-positive B cell enhancer ABC_E9086 Neighboring gene STARR-positive B cell enhancer ABC_E10265 Neighboring gene low density lipoprotein receptor adaptor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E3527 Neighboring gene STARR-seq mESC enhancer starr_11687 Neighboring gene STARR-seq mESC enhancer starr_11688 Neighboring gene STARR-positive B cell enhancer ABC_E2718 Neighboring gene STARR-positive B cell enhancer ABC_E4682 Neighboring gene STARR-seq mESC enhancer starr_11693 Neighboring gene Rh blood group, D antigen Neighboring gene transmembrane protein 50A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Entire sequence of a mouse chromosomal segment containing the gene Rhced and a comparative analysis of the homologous human sequence. Kumada M, et al. Gene, 2002 Oct 16. PMID 12459264
  2. Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. Kuvbachieva A, et al. Eur J Neurosci, 2004 Aug. PMID 15255972
  3. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in brain development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection terminus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in rough endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
macoilin
Names
brain-specific adapter protein C61
brain-specific adaptor protein C61
transmembrane protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355499.1 → NP_001342428.1  macoilin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK038972, AY846873
    UniProtKB/TrEMBL
    Q80YA4
    Conserved Domains (1) summary
    pfam09726
    Location:19 → 606
    Macoilin; Transmembrane protein

  2. NM_001355500.1 → NP_001342429.1  macoilin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AY846873
    UniProtKB/TrEMBL
    Q80YA4
    Conserved Domains (1) summary
    pfam09726
    Location:1 → 485
    Macoilin; Transmembrane protein

  3. NM_001355501.1 → NP_001342430.1  macoilin isoform 3

    Status: VALIDATED

    Source sequence(s)
    AY846873
    UniProtKB/TrEMBL
    Q80YA4
    Conserved Domains (1) summary
    pfam09726
    Location:1 → 485
    Macoilin; Transmembrane protein

  4. NM_025382.6 → NP_079658.2  macoilin isoform 1

    See identical proteins and their annotated locations for NP_079658.2

    Status: VALIDATED

    Source sequence(s)
    AY846873
    Consensus CDS
    CCDS18777.1
    UniProtKB/Swiss-Prot
    Q7TQE6
    UniProtKB/TrEMBL
    Q80YA4
    Related
    ENSMUSP00000030628.8, ENSMUST00000030628.15
    Conserved Domains (3) summary
    TIGR03462
    Location:29 → 113
    CarR_dom_SF; lycopene cyclase domain
    pfam09726
    Location:2 → 662
    Macoilin; Transmembrane protein
    pfam16331
    Location:386 → 462
    TolA_bind_tri; TolA binding protein trimerization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    134530070..134581242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164305.1 → XP_036020198.1  macoilin isoform X2

    Conserved Domains (1) summary
    pfam09726
    Location:1 → 238
    Macoilin; Macoilin family

  2. XM_006539100.4 → XP_006539163.1  macoilin isoform X1

    Conserved Domains (1) summary
    pfam09726
    Location:2 → 384
    Macoilin; Macoilin family

RNA

  1. XR_004941943.1 RNA Sequence

  2. XR_001784176.2 RNA Sequence

  3. XR_004941944.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQE6.1 GenPept UniProtKB/Swiss-Prot:Q7TQE6

Gene LinkOut

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