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Ppp1r7 protein phosphatase 1, regulatory subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 66385, updated on 27-Nov-2024

Summary

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Official Symbol
Ppp1r7provided by MGI
Official Full Name
protein phosphatase 1, regulatory subunit 7provided by MGI
Primary source
MGI:MGI:1913635
See related
Ensembl:ENSMUSG00000026275 AllianceGenome:MGI:1913635
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDS22; 2310014J01Rik
Summary
Predicted to enable protein phosphatase regulator activity. Acts upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ppp1r7 in Genome Data Viewer
Location:
1 D; 1 47.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93271350..93295344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93343610..93367616)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28535 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene PAS domain containing serine/threonine kinase Neighboring gene STARR-positive B cell enhancer ABC_E3291 Neighboring gene STARR-positive B cell enhancer ABC_E7733 Neighboring gene microRNA 6902 Neighboring gene microRNA 6345 Neighboring gene predicted gene, 26446 Neighboring gene anoctamin 7 Neighboring gene high density lipoprotein (HDL) binding protein Neighboring gene predicted gene, 17415

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetically regulated expression of UDP-N-acetylgalactosamine: GM3(NeuGc) N-acetylgalactosaminyltransferase [EC 2.4.1.92] activity in mouse liver. Hashimoto Y, et al. J Biochem, 1984 Jun. PMID 6432773
  2. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. Ceulemans H, et al. Eur J Biochem, 1999 May. PMID 10231361
  3. Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN. Katschinski DM, et al. Mol Cell Biol, 2003 Oct. PMID 12972598, Free PMC Article
  4. Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation. Goswami S, et al. J Cell Physiol, 2019 Mar. PMID 30144392, Free PMC Article
  5. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. Chiang DY, et al. J Am Coll Cardiol, 2015 Jan 20. PMID 25593058, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The three regulators (PPP1R2, PPP1R7, and PPP1R11)share localization with PP1gamma2 in the head and the principal piece of sperm. We show that the association of inhibitors to PP1gamma2 changes during epididymal sperm maturation. In immotile caput epididymal sperm, PPP1R2 and PPP1R7 are not bound to PP1gamma2, whereas in motile caudal sperm, all three inhibitors are bound as heterodimers or heterotrimers.
    Title: Regulators of the protein phosphatase PP1γ2, PPP1R2, PPP1R7, and PPP1R11 are involved in epididymal sperm maturation.
  2. Ppp1r7 may play a central role in regulating the PP1 interactome by acting as a competitive molecular "sponge" of PP1c during heart failure progression.
    Title: Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 7
Names
protein phosphatase 1 regulatory subunit 22
protein phosphatase 1, regulatory (inhibitor) subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023200.3 → NP_075689.1  protein phosphatase 1 regulatory subunit 7

    See identical proteins and their annotated locations for NP_075689.1

    Status: VALIDATED

    Source sequence(s)
    AC124669, AK031983
    Consensus CDS
    CCDS15187.1
    UniProtKB/Swiss-Prot
    Q3UM45, Q9CV31, Q9Z105
    Related
    ENSMUSP00000027494.5, ENSMUST00000027494.11
    Conserved Domains (4) summary
    smart00446
    Location:337 → 355
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:101 → 122
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:254 → 295
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:231 → 287
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93271350..93295344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248057.4 → XP_011246359.1  protein phosphatase 1 regulatory subunit 7 isoform X1

    Conserved Domains (3) summary
    smart00446
    Location:184 → 202
    LRRcap; occurring C-terminal to leucine-rich repeats
    sd00033
    Location:14 → 35
    LRR_RI; leucine-rich repeat [structural motif]
    NF033189
    Location:2 → 166
    internalin_A; class 1 internalin InlA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UM45.2 GenPept UniProtKB/Swiss-Prot:Q3UM45

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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