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Coprs coordinator of PRMT5, differentiation stimulator [ Mus musculus (house mouse) ]

Gene ID: 66423, updated on 27-Nov-2024

Summary

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Official Symbol
Coprsprovided by MGI
Official Full Name
coordinator of PRMT5, differentiation stimulatorprovided by MGI
Primary source
MGI:MGI:1913673
See related
Ensembl:ENSMUSG00000031458 AllianceGenome:MGI:1913673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Copr5; 1700029I03Rik; 2410022L05Rik
Summary
Predicted to enable histone binding activity. Involved in muscle organ development. Acts upstream of or within blastocyst hatching. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in early conceptus and secondary oocyte. Orthologous to human COPRS (coordinator of PRMT5 and differentiation stimulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 18.3), CNS E18 (RPKM 11.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Coprs in Genome Data Viewer
Location:
8 A1.1; 8 6.41 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13934787..13940501, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13884787..13890352, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53400 Neighboring gene chromosome alignment maintaining phosphoprotein 1 Neighboring gene predicted gene, 24698 Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene F-box protein 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes. Paul C, et al. FEBS Open Bio, 2019 Jan. PMID 30652083, Free PMC Article
  2. The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion. Paul C, et al. Biol Open, 2015 Feb 13. PMID 25681392, Free PMC Article
  3. The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation. Paul C, et al. Cell Death Differ, 2012 May. PMID 22193545, Free PMC Article
  4. Complete physical map and gene content of the human NF1 tumor suppressor region in human and mouse. Jenne DE, et al. Genes Chromosomes Cancer, 2003 Jun. PMID 12696059
  5. The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5. Lacroix M, et al. EMBO Rep, 2008 May. PMID 18404153, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coordinator of PRMT5 and differentiation stimulator
Names
cooperator of PRMT5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359059.1 → NP_001345988.1  coordinator of PRMT5 and differentiation stimulator isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139186
    Conserved Domains (1) summary
    pfam15340
    Location:10 → 101
    COPR5; Cooperator of PRMT5 family

  2. NM_025556.3 → NP_079832.1  coordinator of PRMT5 and differentiation stimulator isoform 1

    See identical proteins and their annotated locations for NP_079832.1

    Status: VALIDATED

    Source sequence(s)
    AK008882, BY647791
    Consensus CDS
    CCDS40237.1
    UniProtKB/Swiss-Prot
    Q9CQ13
    Related
    ENSMUSP00000033839.8, ENSMUST00000033839.9
    Conserved Domains (1) summary
    pfam15340
    Location:24 → 173
    COPR5; Cooperator of PRMT5 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13934787..13940501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242070.4 → XP_011240372.1  coordinator of PRMT5 and differentiation stimulator isoform X1

    Conserved Domains (1) summary
    pfam15340
    Location:24 → 46
    COPR5; Cooperator of PRMT5 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ13.1 GenPept UniProtKB/Swiss-Prot:Q9CQ13

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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