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Ppdpf pancreatic progenitor cell differentiation and proliferation factor [ Mus musculus (house mouse) ]

Gene ID: 66496, updated on 27-Nov-2024

Summary

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Official Symbol
Ppdpfprovided by MGI
Official Full Name
pancreatic progenitor cell differentiation and proliferation factorprovided by MGI
Primary source
MGI:MGI:1913746
See related
Ensembl:ENSMUSG00000016344 AllianceGenome:MGI:1913746
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012G23Rik; 2610317A05Rik; 2700038C09Rik; 3110053G12Rik
Summary
Acts upstream of or within TORC1 signaling and liver development. Is expressed in several structures, including esophagus; forelimb bud; and male reproductive gland or organ. Used to study metabolic dysfunction-associated steatotic liver disease. Orthologous to human PPDPF (pancreatic progenitor cell differentiation and proliferation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 79.8), colon adult (RPKM 67.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ppdpf in Genome Data Viewer
Location:
2 H4; 2 103.62 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180828615..180830297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181186822..181188504)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 2 Neighboring gene STARR-seq mESC enhancer starr_06747 Neighboring gene predicted gene, 24892 Neighboring gene STARR-positive B cell enhancer ABC_E6039 Neighboring gene PTK6 protein tyrosine kinase 6 Neighboring gene predicted gene, 40033 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1. Ni QZ, et al. Adv Sci (Weinh), 2023 Jan. PMID 36453576, Free PMC Article
  2. PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3. Zheng QW, et al. Oncogene, 2022 Sep. PMID 35906391
  3. PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1. Wang YK, et al. Cell Rep, 2023 Apr 25. PMID 37027301
  4. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling. Ma N, et al. Nat Commun, 2021 May 24. PMID 34031390, Free PMC Article
  5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1.
    Title: PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1.
  2. PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1.
    Title: PPDPF Promotes the Development of Mutant KRAS-Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1.
  3. PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
    Title: PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within TOR signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within TOR signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
pancreatic progenitor cell differentiation and proliferation factor
Names
exocrine differentiation and proliferation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356427.2 → NP_001343356.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL450341
    Consensus CDS
    CCDS17202.1
    UniProtKB/Swiss-Prot
    Q58EU5, Q9CR37
    Related
    ENSMUSP00000104469.2, ENSMUST00000108841.2
    Conserved Domains (1) summary
    pfam15060
    Location:1 → 110
    PPDFL; Differentiation and proliferation regulator

  2. NM_001356428.2 → NP_001343357.1  pancreatic progenitor cell differentiation and proliferation factor isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL450341
    Conserved Domains (1) summary
    pfam15060
    Location:1 → 84
    PPDFL; Differentiation and proliferation regulator

  3. NM_025598.4 → NP_079874.1  pancreatic progenitor cell differentiation and proliferation factor isoform a

    See identical proteins and their annotated locations for NP_079874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AL450341
    Consensus CDS
    CCDS17202.1
    UniProtKB/Swiss-Prot
    Q58EU5, Q9CR37
    Related
    ENSMUSP00000016488.7, ENSMUST00000016488.13
    Conserved Domains (1) summary
    pfam15060
    Location:1 → 110
    PPDFL; Differentiation and proliferation regulator

RNA

  1. NR_151465.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL450341
    Related
    ENSMUST00000146089.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180828615..180830297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR37.1 GenPept UniProtKB/Swiss-Prot:Q9CR37

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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