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Gm14391 predicted gene 14391 [ Mus musculus (house mouse) ]

Gene ID: 665001, updated on 27-Nov-2024

Summary

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Official Symbol
Gm14391provided by MGI
Official Full Name
predicted gene 14391provided by MGI
Primary source
MGI:MGI:3709324
See related
Ensembl:ENSMUSG00000078903 AllianceGenome:MGI:3709324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF17 (zinc finger protein 17) and ZNF442 (zinc finger protein 442). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 2.6), frontal lobe adult (RPKM 2.6) and 24 other tissues See more
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Genomic context

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See Gm14391 in Genome Data Viewer
Location:
2 H4; 2 98.31 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (175026958..175048717, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (175185165..175206924, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 14387 Neighboring gene STARR-seq mESC enhancer starr_06657 Neighboring gene predicted gene 14393 Neighboring gene predicted gene 14439 Neighboring gene STARR-seq mESC enhancer starr_06658 Neighboring gene predicted gene 14399 Neighboring gene STARR-seq mESC enhancer starr_06659 Neighboring gene STARR-positive B cell enhancer mm9_chr2:175032331-175032631 Neighboring gene predicted gene 14438 Neighboring gene zinc finger protein 1009

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KRAB box and zinc finger, C2H2 type domain containing

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099308.2 → NP_001092778.1  KRAB box and zinc finger, C2H2 type domain containing isoform 1

    See identical proteins and their annotated locations for NP_001092778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1), which includes an N-terminal KRAB box and several C2H2-type zinc fingers.
    Source sequence(s)
    AL845494
    Consensus CDS
    CCDS38363.1
    UniProtKB/TrEMBL
    A2ART0, F7CJX1
    Related
    ENSMUSP00000104686.3, ENSMUST00000109058.9
    Conserved Domains (4) summary
    COG5048
    Location:129 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:357 → 377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box
    pfam13465
    Location:509 → 534
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001177480.1 → NP_001170951.1  KRAB box and zinc finger, C2H2 type domain containing isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus that lacks the C2H2-type zinc fingers, compared to isoform 1.
    Source sequence(s)
    AK013829
    UniProtKB/TrEMBL
    A2BE16
    Related
    ENSMUSP00000104683.2, ENSMUST00000109055.2
    Conserved Domains (2) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    pfam01352
    Location:4 → 43
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    175026958..175048717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251945.1 → XP_030107805.1  KRAB box and zinc finger, C2H2 type domain containing isoform X1

    UniProtKB/TrEMBL
    A2ART0, F7CJX1
    Conserved Domains (4) summary
    COG5048
    Location:129 → 515
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:357 → 377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box
    pfam13465
    Location:509 → 534
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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