Zscan4f zinc finger and SCAN domain containing 4F [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zscan4fprovided by MGI
Official Full Name: zinc finger and SCAN domain containing 4Fprovided by MGI
Primary source: MGI:MGI:3708485
See related: Ensembl:ENSMUSG00000070828 AllianceGenome:MGI:3708485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C330039H09Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and telomere maintenance via telomere lengthening. Predicted to be located in chromosome, telomeric region. Is expressed in 2-cell stage embryo. Orthologous to human ZSCAN4 (zinc finger and SCAN domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 A1; 7 7.0 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (11131842..11136245)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (11397915..11402318)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zscan4f, in combination with the Yamanaka factors, not only remarkably reduced the DDR but also markedly promoted the efficiency of iPS cell generation.
Title: Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance via telomere lengthening	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: zinc finger and SCAN domain containing protein 4F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110316.2 → NP_001103786.2 zinc finger and SCAN domain containing protein 4F

See identical proteins and their annotated locations for NP_001103786.2

Status: VALIDATED

Source sequence(s)

AK141250, CN715580

Consensus CDS

CCDS52015.1

UniProtKB/Swiss-Prot

Q3URS2

UniProtKB/TrEMBL

A0A1C7CYU6

Related

ENSMUSP00000120149.2, ENSMUST00000145237.8

Conserved Domains (4) summary

sd00017
Location:426 → 446

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:395 → 417

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:438 → 463

zf-H2C2_2; Zinc-finger double domain

cl02605
Location:51 → 117

SCAN; SCAN oligomerization domain