Defa43 defensin, alpha, 43 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Defa43provided by MGI
Official Full Name: defensin, alpha, 43provided by MGI
Primary source: MGI:MGI:3648003
See related: Ensembl:ENSMUSG00000079113 AllianceGenome:MGI:3648003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm7861; EG665956
Summary: Predicted to enable protein homodimerization activity. Predicted to be located in azurophil granule. Orthologous to human DEFA4 (defensin alpha 4) and DEFA6 (defensin alpha 6). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward large intestine adult (RPKM 1448.0) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8 A2; 8 10.35 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (22083503..22084481, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (21593487..21594465, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in azurophil granule	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: alpha-defensin 43

Names: novel defensin-related cryptidin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.