Tmigd1 transmembrane and immunoglobulin domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmigd1provided by MGI
Official Full Name: transmembrane and immunoglobulin domain containing 1provided by MGI
Primary source: MGI:MGI:1913851
See related: Ensembl:ENSMUSG00000020839 AllianceGenome:MGI:1913851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmigd; 2010002A20Rik
Summary: Enables cell-cell adhesion mediator activity and protein homodimerization activity. Involved in cell-cell adhesion. Acts upstream of or within several processes, including brush border assembly; cellular response to hydroperoxide; and intestinal epithelial cell maturation. Is active in cell surface. Orthologous to human TMIGD1 (transmembrane and immunoglobulin domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 33.2) and kidney adult (RPKM 9.3) See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.15 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (76781946..76807413)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (76891120..76916587)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223.
Title: Macrophage-derived exosomes promote intestinal mucosal barrier dysfunction in inflammatory bowel disease by regulating TMIGD1 via mircroRNA-223.
Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-kappaB pathway in Crohn's disease.
Title: Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn's disease.
Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex.
Title: Intestinal brush border formation requires a TMIGD1-based intermicrovillar adhesion complex.
TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.
Title: TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells.
The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration.
Title: The cell adhesion molecule TMIGD1 binds to moesin and regulates tubulin acetylation and cell migration.
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
Title: Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Gene trapped (1)

General gene information

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Markers

D11Mit244 (e-PCR), detects polymorphism
- UniSTS:126444

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	IDA Inferred from Direct Assay more info	PubMed
enables cell-cell adhesion mediator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within brush border assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell aggregation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to hydroperoxide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intestinal epithelial cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cyclin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane permeability	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to nutrient	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane and immunoglobulin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001382246.1 → NP_001369175.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL603842

UniProtKB/TrEMBL

Q9D8H2

Conserved Domains (2) summary

smart00410
Location:163 → 244

IG_like; Immunoglobulin like

cd00096
Location:171 → 175

Ig; Ig strand B [structural motif]
NM_001382247.1 → NP_001369176.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

AL603842

UniProtKB/TrEMBL

Q9D8H2

Conserved Domains (2) summary

smart00410
Location:163 → 244

IG_like; Immunoglobulin like

cd00096
Location:171 → 175

Ig; Ig strand B [structural motif]
NM_025655.3 → NP_079931.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_079931.1

Status: VALIDATED

Source sequence(s)

AL603842

Consensus CDS

CCDS25072.1

UniProtKB/Swiss-Prot

Q8R202, Q9D7L8

UniProtKB/TrEMBL

Q9D8H2

Related

ENSMUSP00000099553.2, ENSMUST00000102495.8

Conserved Domains (1) summary

smart00409
Location:130 → 211

IG; Immunoglobulin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

76781946..76807413

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533950.3 → XP_006534013.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X2

See identical proteins and their annotated locations for XP_006534013.1

UniProtKB/Swiss-Prot

Q8R202, Q9D7L8

UniProtKB/TrEMBL

Q9D8H2

Conserved Domains (1) summary

smart00409
Location:130 → 211

IG; Immunoglobulin
XM_036156900.1 → XP_036012793.1 transmembrane and immunoglobulin domain-containing protein 1 isoform X1

UniProtKB/TrEMBL

Q9D8H2

Conserved Domains (2) summary

smart00410
Location:163 → 244

IG_like; Immunoglobulin like

cd00096
Location:171 → 175

Ig; Ig strand B [structural motif]