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Cryzl1 crystallin zeta like 1 [ Mus musculus (house mouse) ]

Gene ID: 66609, updated on 27-Nov-2024

Summary

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Official Symbol
Cryzl1provided by MGI
Official Full Name
crystallin zeta like 1provided by MGI
Primary source
MGI:MGI:1913859
See related
Ensembl:ENSMUSG00000058240 AllianceGenome:MGI:1913859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
QOH-1; 2210407J23Rik; 2410006O11Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be located in early endosome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CRYZL1 (crystallin zeta like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.6), CNS E14 (RPKM 13.0) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Cryzl1 in Genome Data Viewer
Location:
16 C4; 16 53.26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91486210..91525690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91689300..91729206, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E2468 Neighboring gene downstream neighbor of SON Neighboring gene predicted gene 10785 Neighboring gene predicted gene, 46543 Neighboring gene intersectin 1 (SH3 domain protein 1A) Neighboring gene predicted gene, 53921 Neighboring gene predicted gene, 52262

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  2. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
  3. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
quinone oxidoreductase-like protein 1
Names
crystallin, zeta (quinone reductase)-like 1
ferry endosomal RAB5 effector complex subunit 4
quinone oxidoreductase homolog 1
zeta-crystallin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026994.1 → NP_081270.1  quinone oxidoreductase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_081270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC131691
    Consensus CDS
    CCDS57039.1
    UniProtKB/TrEMBL
    D3YZD6, D3Z6I4
    Related
    ENSMUSP00000113227.2, ENSMUST00000117644.8
    Conserved Domains (2) summary
    cd05195
    Location:31 → 331
    enoyl_red; enoyl reductase of polyketide synthase
    COG0604
    Location:1 → 310
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

  2. NM_133679.2 → NP_598440.1  quinone oxidoreductase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_598440.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145827, BU757748, BY717916
    Consensus CDS
    CCDS37401.1
    UniProtKB/Swiss-Prot
    Q3UKX2, Q8VCS1, Q921W4, Q9CWR9
    UniProtKB/TrEMBL
    D3YZD6
    Related
    ENSMUSP00000073171.7, ENSMUST00000073466.13
    Conserved Domains (1) summary
    cd05195
    Location:31 → 346
    enoyl_red; enoyl reductase of polyketide synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91486210..91525690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921W4.1 GenPept UniProtKB/Swiss-Prot:Q921W4

Gene LinkOut

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