U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nepn nephrocan [ Mus musculus (house mouse) ]

Gene ID: 66650, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Nepnprovided by MGI
Official Full Name
nephrocanprovided by MGI
Primary source
MGI:MGI:1913900
See related
Ensembl:ENSMUSG00000038624 AllianceGenome:MGI:1913900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npn; periolin; 5730521E12Rik
Summary
Acts upstream of or within extracellular matrix organization; negative regulation of transcription by RNA polymerase II; and negative regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space and interstitial matrix. Is expressed in several structures, including embryo endoderm; genitourinary system; gut; humerus; and musculature. Orthologous to human NEPNP (nephrocan, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in kidney adult (RPKM 8.0), subcutaneous fat pad adult (RPKM 0.6) and 1 other tissue See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nepn in Genome Data Viewer
Location:
10 B3; 10 26.6 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (52264961..52280707)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (52388864..52404611)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene golgi associated PDZ and coiled-coil motif containing Neighboring gene ribosomal protein S19, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_26676 Neighboring gene STARR-positive B cell enhancer ABC_E2933 Neighboring gene NUS1 dehydrodolichyl diphosphate synthase subunit Neighboring gene STARR-seq mESC enhancer starr_26679 Neighboring gene STARR-seq mESC enhancer starr_26680 Neighboring gene predicted gene, 47612

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pancreatic Progenitor Commitment Is Marked by an Increase in Ink4a/Arf Expression. Montano E, et al. Biomolecules, 2021 Jul 30. PMID 34439790, Free PMC Article
  2. Insight into Nephrocan Function in Mouse Endoderm Patterning. Addeo M, et al. Int J Mol Sci, 2019 Dec 18. PMID 31861348, Free PMC Article
  3. Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. Mochida Y, et al. J Biol Chem, 2006 Nov 24. PMID 16990280
  4. miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm. Yang D, et al. Development, 2014 Feb. PMID 24449834
  5. Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm. Wang Z, et al. Nat Commun, 2022 Sep 19. PMID 36123357, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A regulatory network, incluing Sox17 and the retinoic acid receptor, controls nephrocan expression and midgut patterning.
    Title: A regulatory network controls nephrocan expression and midgut patterning.
  2. NPN is a novel member of the SLRP family that may play important roles in kidney development and pathophysiology by functioning as an endogenous inhibitor of TGF-beta signaling
    Title: Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nephrocan

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025684.3 → NP_079960.1  nephrocan precursor

    See identical proteins and their annotated locations for NP_079960.1

    Status: VALIDATED

    Source sequence(s)
    AC153526
    Consensus CDS
    CCDS23840.1
    UniProtKB/Swiss-Prot
    Q9CQ76
    Related
    ENSMUSP00000070130.5, ENSMUST00000067085.7
    Conserved Domains (3) summary
    cd00116
    Location:210 → 425
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:188 → 211
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:367 → 426
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    52264961..52280707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512818.5 → XP_006512881.1  nephrocan isoform X1

    Conserved Domains (2) summary
    PRK15370
    Location:271 → 474
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:237 → 260
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_006512819.5 → XP_006512882.1  nephrocan isoform X2

    Conserved Domains (2) summary
    PRK15370
    Location:161 → 364
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:127 → 150
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ76.1 GenPept UniProtKB/Swiss-Prot:Q9CQ76

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools