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Sorcs3 sortilin-related VPS10 domain containing receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 66673, updated on 27-Nov-2024

Summary

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Official Symbol
Sorcs3provided by MGI
Official Full Name
sortilin-related VPS10 domain containing receptor 3provided by MGI
Primary source
MGI:MGI:1913923
See related
Ensembl:ENSMUSG00000063434 AllianceGenome:MGI:1913923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330404A12Rik
Summary
Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within learning; memory; and regulation of long-term synaptic depression. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; cochlea; genitourinary system; retina; and trigeminal ganglion. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 4.4), frontal lobe adult (RPKM 4.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Sorcs3 in Genome Data Viewer
Location:
19 D1; 19 41.32 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (48194464..48793944)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (48206025..48805505)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47993319-47993502 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:47994118-47994301 Neighboring gene STARR-positive B cell enhancer mm9_chr19:48011969-48012270 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein Neighboring gene cilia and flagella associated protein 58 Neighboring gene STARR-seq mESC enhancer starr_46376 Neighboring gene STARR-seq mESC enhancer starr_46378 Neighboring gene STARR-seq mESC enhancer starr_46379 Neighboring gene STARR-seq mESC enhancer starr_46381 Neighboring gene STARR-seq mESC enhancer starr_46382 Neighboring gene STARR-seq mESC enhancer starr_46383 Neighboring gene STARR-seq mESC enhancer starr_46384 Neighboring gene STARR-seq mESC enhancer starr_46385 Neighboring gene STARR-seq mESC enhancer starr_46386 Neighboring gene STARR-seq mESC enhancer starr_46387 Neighboring gene STARR-seq mESC enhancer starr_46388 Neighboring gene STARR-seq mESC enhancer starr_46389 Neighboring gene STARR-seq mESC enhancer starr_46390 Neighboring gene STARR-seq mESC enhancer starr_46391 Neighboring gene STARR-seq mESC enhancer starr_46392 Neighboring gene STARR-seq mESC enhancer starr_46393 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene siah E3 ubiquitin protein ligase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus. Christiansen GB, et al. Hippocampus, 2017 Mar. PMID 27935149
  2. SORCS1 and SORCS3 control energy balance and orexigenic peptide production. Subkhangulova A, et al. EMBO Rep, 2018 Apr. PMID 29440124, Free PMC Article
  3. Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice. Hermey G, et al. Biol Chem, 2019 Aug 27. PMID 31095505
  4. Spatiotemporal expression analysis of the growth factor receptor SorCS3. Oetjen S, et al. J Comp Neurol, 2014 Oct 15. PMID 24715575
  5. The three sorCS genes are differentially expressed and regulated by synaptic activity. Hermey G, et al. J Neurochem, 2004 Mar. PMID 15009648

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex
    Title: Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.
  2. our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
    Title: SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
  3. SorCS3 serves as a key regulator of synaptic transmission and plasticity. Results show that glutamate receptor functions are controlled by SorCS3 to secure correct functioning of excitatory synapses. The receptor plays a more central role in CA1 compared to the dentate gyrus, correlating well with the expression pattern. Reduced function of SorCS3 results in impaired synaptic mechanisms in the hippocampus.
    Title: The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.
  4. Study demonstrates that SorCS3 expression is restricted to the developing and adult nervous system
    Title: Spatiotemporal expression analysis of the growth factor receptor SorCS3.
  5. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
    Title: Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
  6. SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
    Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
VPS10 domain-containing receptor SorCS3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025696.3 → NP_079972.1  VPS10 domain-containing receptor SorCS3 precursor

    See identical proteins and their annotated locations for NP_079972.1

    Status: VALIDATED

    Source sequence(s)
    AC122363, AC126046, AC127434, AC141870
    Consensus CDS
    CCDS38020.1
    UniProtKB/Swiss-Prot
    Q8VI51, Q9CTR4
    UniProtKB/TrEMBL
    Q1HL22
    Related
    ENSMUSP00000077919.6, ENSMUST00000078880.6
    Conserved Domains (3) summary
    smart00602
    Location:216 → 814
    VPS10; VPS10 domain
    pfam00801
    Location:828 → 901
    PKD; PKD domain
    pfam15901
    Location:658 → 814
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    48194464..48793944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI51.1 GenPept UniProtKB/Swiss-Prot:Q8VI51

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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