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Bzw1 basic leucine zipper and W2 domains 1 [ Mus musculus (house mouse) ]

Gene ID: 66882, updated on 27-Nov-2024

Summary

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Official Symbol
Bzw1provided by MGI
Official Full Name
basic leucine zipper and W2 domains 1provided by MGI
Primary source
MGI:MGI:1914132
See related
Ensembl:ENSMUSG00000051223 AllianceGenome:MGI:1914132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0005; 1200015E15Rik
Summary
Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Is expressed in early conceptus. Orthologous to human BZW1 (basic leucine zipper and W2 domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 69.8), CNS E18 (RPKM 52.7) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Bzw1 in Genome Data Viewer
Location:
1 C1.3; 1 29.09 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58432057..58446513)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58392898..58407354)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 2 Neighboring gene predicted gene 15759 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58450605-58450792 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 53481 Neighboring gene STARR-seq mESC enhancer starr_01013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58480276-58480459 Neighboring gene STARR-positive B cell enhancer ABC_E5756 Neighboring gene CDC-like kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Alternative 3' UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression. Yu M, et al. Biochem Biophys Res Commun, 2006 Jun 23. PMID 16690031
  2. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation. Zhang J, et al. Nat Commun, 2022 Nov 4. PMID 36333315, Free PMC Article
  3. Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice. Qi H, et al. Cell Mol Biol Lett, 2023 Oct 12. PMID 37828427, Free PMC Article
  4. Pin1 Regulates IL-5 Induced Eosinophil Polarization and Migration. Shen ZJ, et al. Cells, 2021 Jan 21. PMID 33494375, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of BZW1 by CEBPB in macrophages promotes eIF2alpha phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
    Title: Activation of BZW1 by CEBPB in macrophages promotes eIF2α phosphorylation-mediated metabolic reprogramming and endoplasmic reticulum stress in MRL/lpr lupus-prone mice.
  2. Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.
    Title: Translation regulatory factor BZW1 regulates preimplantation embryo development and compaction by restricting global non-AUG Initiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6434

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eIF5-mimic protein 2
Names
basic leucine zipper and W2 domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025824.4 → NP_080100.1  eIF5-mimic protein 2

    See identical proteins and their annotated locations for NP_080100.1

    Status: VALIDATED

    Source sequence(s)
    AC121091, AK076560, AK161192, CJ085444
    Consensus CDS
    CCDS14971.1
    UniProtKB/Swiss-Prot
    Q3THS5, Q3UZ94, Q9CQC6
    Related
    ENSMUSP00000051935.9, ENSMUST00000050552.15
    Conserved Domains (1) summary
    cd11560
    Location:217 → 406
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58432057..58446513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322066.1 → XP_017177555.1  eIF5-mimic protein 2 isoform X1

    Conserved Domains (1) summary
    cd11560
    Location:133 → 322
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQC6.1 GenPept UniProtKB/Swiss-Prot:Q9CQC6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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