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Sh3d21 SH3 domain containing 21 [ Mus musculus (house mouse) ]

Gene ID: 66938, updated on 27-Nov-2024

Summary

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Official Symbol
Sh3d21provided by MGI
Official Full Name
SH3 domain containing 21provided by MGI
Primary source
MGI:MGI:1914188
See related
Ensembl:ENSMUSG00000073758 AllianceGenome:MGI:1914188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700029G01Rik
Summary
Predicted to be involved in actin filament organization and cell migration. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human SH3D21 (SH3 domain containing 21). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 90.1) and colon adult (RPKM 8.7) See more
Orthologs
human all
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Genomic context

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See Sh3d21 in Genome Data Viewer
Location:
4 D2.2; 4 59.97 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126044395..126057503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126150602..126163518, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene serine/threonine kinase 40 Neighboring gene eva-1 homolog B Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125839584-125839767 Neighboring gene STARR-seq mESC enhancer starr_11390 Neighboring gene thyroid hormone receptor associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_11391 Neighboring gene STARR-seq mESC enhancer starr_11392 Neighboring gene predicted gene, 25323 Neighboring gene MAP7 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
  2. The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Inoue K, et al. Cell Rep, 2017 May 2. PMID 28467908
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing protein 21
Names
SH3 domain-containing protein C1orf113 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162533.1 → NP_001156005.1  SH3 domain-containing protein 21 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL731780
    Consensus CDS
    CCDS51301.1
    UniProtKB/TrEMBL
    Z4YK11
    Related
    ENSMUSP00000095501.4, ENSMUST00000097891.4
    Conserved Domains (3) summary
    cd11874
    Location:87 → 139
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:186 → 239
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:2 → 55
    SH3; Src Homology 3 domain superfamily

  2. NM_025856.3 → NP_080132.1  SH3 domain-containing protein 21 isoform 2

    See identical proteins and their annotated locations for NP_080132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and lacks an alternate exon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK011430, AK076962, AL731780, BF452472
    Consensus CDS
    CCDS18644.1
    UniProtKB/Swiss-Prot
    B1AW04, Q3U2S3, Q7TSG5
    Related
    ENSMUSP00000092352.3, ENSMUST00000094760.9
    Conserved Domains (2) summary
    PTZ00449
    Location:144 → 475
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd12142
    Location:70 → 123
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126044395..126057503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253709.2 → XP_030109569.1  SH3 domain-containing protein 21 isoform X3

    Conserved Domains (3) summary
    PTZ00449
    Location:232 → 563
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11874
    Location:59 → 111
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:158 → 211
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

  2. XM_036164353.1 → XP_036020246.1  SH3 domain-containing protein 21 isoform X6

  3. XM_030253708.2 → XP_030109568.1  SH3 domain-containing protein 21 isoform X2

    Conserved Domains (3) summary
    PTZ00449
    Location:233 → 564
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11874
    Location:60 → 112
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:159 → 212
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins

  4. XM_030253707.2 → XP_030109567.1  SH3 domain-containing protein 21 isoform X1

    Conserved Domains (4) summary
    PTZ00449
    Location:259 → 590
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11874
    Location:86 → 138
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:185 → 238
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:2 → 55
    SH3; Src Homology 3 domain superfamily

  5. XM_030253710.2 → XP_030109570.1  SH3 domain-containing protein 21 isoform X4

    Conserved Domains (4) summary
    PTZ00449
    Location:260 → 591
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd11874
    Location:87 → 139
    SH3_CD2AP-like_2; Second Src Homology 3 domain (SH3B) of CD2-associated protein and similar proteins
    cd12142
    Location:186 → 239
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
    cl17036
    Location:2 → 55
    SH3; Src Homology 3 domain superfamily

  6. XM_036164354.1 → XP_036020247.1  SH3 domain-containing protein 21 isoform X6

    Conserved Domains (1) summary
    PHA03247
    Location:37 → 359
    PHA03247; large tegument protein UL36; Provisional

  7. XM_030253711.2 → XP_030109571.1  SH3 domain-containing protein 21 isoform X5

    UniProtKB/Swiss-Prot
    B1AW04, Q3U2S3, Q7TSG5
    Conserved Domains (2) summary
    PTZ00449
    Location:144 → 475
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd12142
    Location:70 → 123
    SH3_D21-like; Src Homology 3 domain of SH3 domain-containing protein 21 (SH3D21) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSG5.1 GenPept UniProtKB/Swiss-Prot:Q7TSG5

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