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Herc4 hect domain and RLD 4 [ Mus musculus (house mouse) ]

Gene ID: 67345, updated on 27-Nov-2024

Summary

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Official Symbol
Herc4provided by MGI
Official Full Name
hect domain and RLD 4provided by MGI
Primary source
MGI:MGI:1914595
See related
Ensembl:ENSMUSG00000020064 AllianceGenome:MGI:1914595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1593; 1700056O17Rik; 4921531D01Rik; 9530080M15Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in spermatogenesis. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm. Orthologous to human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 13.5), bladder adult (RPKM 8.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Herc4 in Genome Data Viewer
Location:
10 B4; 10 32.56 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63079122..63153660)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63243751..63317881)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26919 Neighboring gene atonal bHLH transcription factor 7 Neighboring gene myopalladin Neighboring gene STARR-seq mESC enhancer starr_26921 Neighboring gene STARR-seq mESC enhancer starr_26922 Neighboring gene STARR-seq mESC enhancer starr_26924 Neighboring gene STARR-seq mESC enhancer starr_26926 Neighboring gene RIKEN cDNA 1700120B22 gene Neighboring gene predicted gene, 51767 Neighboring gene Sirt1 promoter region Neighboring gene sirtuin 1 Neighboring gene STARR-seq mESC enhancer starr_26931 Neighboring gene STARR-seq mESC enhancer starr_26932 Neighboring gene STARR-positive B cell enhancer ABC_E5142 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice. Zhang Z, et al. Blood, 2016 Mar 31. PMID 26825710
  2. Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility. Rodriguez CI, et al. Dev Biol, 2007 Dec 15. PMID 17967448
  3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HERC4 plays an important role in Multiple myeloma progression.
    Title: The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
  2. The E3 ubiquitin ligase Herc4, though ubiquitously expressed in all tissues, is most highly expressed in the testis, specifically during spermiogenesis
    Title: Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC4
Names
HECT domain and RCC1-like domain-containing protein 4
HECT-type E3 ubiquitin transferase HERC4
NP_001346413.1
NP_080377.2
NP_084390.1
XP_006514049.1
XP_006514052.1
XP_006514053.1
XP_030101093.1
XP_030101094.1
XP_036011855.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359484.2 → NP_001346413.1  probable E3 ubiquitin-protein ligase HERC4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive in-frame exons in the central coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AC153516, AC155909
    Conserved Domains (2) summary
    cd00078
    Location:580 → 926
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. NM_001429479.1 → NP_001416408.1  probable E3 ubiquitin-protein ligase HERC4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153516, AC155909

  3. NM_001429480.1 → NP_001416409.1  probable E3 ubiquitin-protein ligase HERC4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153516, AC155909

  4. NM_001429481.1 → NP_001416410.1  probable E3 ubiquitin-protein ligase HERC4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153516, AC155909

  5. NM_026101.5 → NP_080377.2  probable E3 ubiquitin-protein ligase HERC4 isoform 2

    See identical proteins and their annotated locations for NP_080377.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC153516, AC155909
    Consensus CDS
    CCDS23897.1
    UniProtKB/Swiss-Prot
    Q6PAV2
    Related
    ENSMUSP00000020258.9, ENSMUST00000020258.10
    Conserved Domains (3) summary
    smart00119
    Location:727 → 1046
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:701 → 1047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208 → 257
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  6. NM_030114.3 → NP_084390.1  probable E3 ubiquitin-protein ligase HERC4 isoform 1

    See identical proteins and their annotated locations for NP_084390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153516, AC155909
    Consensus CDS
    CCDS88014.1
    UniProtKB/Swiss-Prot
    Q3UL34, Q3UPX2, Q6PAV2, Q810A0, Q811C9, Q8R315, Q9D797
    Related
    ENSMUSP00000151886.2, ENSMUST00000219577.2
    Conserved Domains (3) summary
    smart00119
    Location:735 → 1054
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:709 → 1055
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208 → 257
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RNA

  1. NR_190737.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153516, AC155909

  2. NR_190738.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153516, AC155909

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63079122..63153660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513989.4 → XP_006514052.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    Conserved Domains (2) summary
    cd00078
    Location:454 → 800
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:5 → 53
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_006513986.4 → XP_006514049.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

    Conserved Domains (2) summary
    COG5184
    Location:2 → 344
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:588 → 934
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_030245233.1 → XP_030101093.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    Conserved Domains (2) summary
    COG5184
    Location:12 → 268
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:639 → 985
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  4. XM_030245234.1 → XP_030101094.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    Conserved Domains (2) summary
    cd00078
    Location:454 → 800
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:5 → 53
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  5. XM_036155962.1 → XP_036011855.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    Conserved Domains (1) summary
    cd00078
    Location:250 → 596
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_006513990.3 → XP_006514053.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    Conserved Domains (2) summary
    cd00078
    Location:446 → 792
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:5 → 53
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RNA

  1. XR_003948785.2 RNA Sequence

  2. XR_380431.5 RNA Sequence

  3. XR_003948784.2 RNA Sequence

  4. XR_003948786.2 RNA Sequence

  5. XR_004936261.1 RNA Sequence

  6. XR_004936260.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PAV2.2 GenPept UniProtKB/Swiss-Prot:Q6PAV2

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