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Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 67484, updated on 27-Nov-2024

Summary

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Official Symbol
Eepd1provided by MGI
Official Full Name
endonuclease/exonuclease/phosphatase family domain containing 1provided by MGI
Primary source
MGI:MGI:1914734
See related
Ensembl:ENSMUSG00000036611 AllianceGenome:MGI:1914734
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310005P05Rik
Summary
Predicted to enable DNA binding activity and catalytic activity. Involved in positive regulation of cholesterol efflux. Predicted to be active in plasma membrane. Is expressed in cerebral cortex ventricular layer; dorsal root ganglion; facial ganglion; orbito-sphenoid; and trigeminal ganglion. Orthologous to human EEPD1 (endonuclease/exonuclease/phosphatase family domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 40.4), genital fat pad adult (RPKM 22.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Eepd1 in Genome Data Viewer
Location:
9 A4; 9 10.25 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (25392809..25515406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (25481513..25604110)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23600 Neighboring gene predicted gene, 18891 Neighboring gene STARR-seq mESC enhancer starr_23601 Neighboring gene STARR-positive B cell enhancer ABC_E8281 Neighboring gene ClpB caseinolytic peptidase B homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_23602 Neighboring gene STARR-seq mESC enhancer starr_23603 Neighboring gene predicted gene, 25861 Neighboring gene predicted gene, 25346 Neighboring gene STARR-seq mESC enhancer starr_23604 Neighboring gene STARR-seq mESC enhancer starr_23607 Neighboring gene STARR-seq mESC enhancer starr_23608 Neighboring gene STARR-seq mESC enhancer starr_23609 Neighboring gene predicted gene, 39312 Neighboring gene squamous cell carcinoma antigen recognized by T-cells 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation. Xiong J, et al. Adv Sci (Weinh), 2024 Sep. PMID 38924647, Free PMC Article
  2. EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Nelson JK, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28082258, Free PMC Article
  3. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation.
    Title: Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation.
  2. EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.
    Title: EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endonuclease/exonuclease/phosphatase family domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026189.3 → NP_080465.3  endonuclease/exonuclease/phosphatase family domain-containing protein 1

    See identical proteins and their annotated locations for NP_080465.3

    Status: VALIDATED

    Source sequence(s)
    AA543616, AK009180, AW050261, BY127756, CK619108
    Consensus CDS
    CCDS22935.1
    UniProtKB/Swiss-Prot
    Q3TGW2, Q69ZC7, Q8K3B5, Q9D7J3
    Related
    ENSMUSP00000047083.6, ENSMUST00000040677.6
    Conserved Domains (3) summary
    cd10283
    Location:261 → 538
    MnuA_DNase1-like; Mycoplasma pulmonis MnuA nuclease-like
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:37 → 95
    HHH_3; Helix-hairpin-helix motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    25392809..25515406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155199.1 → XP_036011092.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X1

    Conserved Domains (3) summary
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:35 → 95
    HHH_3; Helix-hairpin-helix motif
    cl00490
    Location:261 → 440
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. XM_006510556.5 → XP_006510619.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:35 → 95
    HHH_3; Helix-hairpin-helix motif

  3. XM_036155200.1 → XP_036011093.1  endonuclease/exonuclease/phosphatase family domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    COG1555
    Location:43 → 195
    ComEA; DNA uptake protein ComE and related DNA-binding proteins [Replication, recombination and repair]
    pfam12836
    Location:35 → 95
    HHH_3; Helix-hairpin-helix motif

RNA

  1. XR_004935523.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TGW2.1 GenPept UniProtKB/Swiss-Prot:Q3TGW2

Gene LinkOut

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