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SSRP1 structure specific recognition protein 1 [ Homo sapiens (human) ]

Gene ID: 6749, updated on 27-Nov-2024

Summary

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Official Symbol
SSRP1provided by HGNC
Official Full Name
structure specific recognition protein 1provided by HGNC
Primary source
HGNC:HGNC:11327
See related
Ensembl:ENSG00000149136 MIM:604328; AllianceGenome:HGNC:11327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FACT; T160; FACT80
Summary
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 33.5), ovary (RPKM 32.7) and 25 other tissues See more
Orthologs
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Genomic context

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See SSRP1 in Genome Data Viewer
Location:
11q12.1
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57325988..57335892, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57275479..57285383, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57093462..57103366, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57051243-57052127 Neighboring gene MPRA-validated peak1278 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57067393-57068592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57070511-57071048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071049-57071584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57071585-57072121 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3344 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57092719-57093592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4714 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4716 Neighboring gene purinergic receptor P2X 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57117303-57117802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:57132373-57132874 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:57136946-57138145 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:57146812-57148011 Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. Chen P, et al. Mol Cell, 2018 Jul 19. PMID 30029006
  2. A role for SSRP1 in recombination-mediated DNA damage response. Kumari A, et al. J Cell Biochem, 2009 Oct 1. PMID 19639603, Free PMC Article
  3. Structure-specific recognition protein 1 facilitates microtubule growth and bundling required for mitosis. Zeng SX, et al. Mol Cell Biol, 2010 Feb. PMID 19995907, Free PMC Article
  4. Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. Kundu LR, et al. Biochim Biophys Acta, 2011 Jun. PMID 21232560, Free PMC Article
  5. Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding. Zhang W, et al. Sci Rep, 2015 Dec 21. PMID 26687053, Free PMC Article

See all (295) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
    Title: Hypoxia-inducible factor 1 recruits FACT and RNF20/40 to mediate histone ubiquitination and transcriptional activation of target genes.
  2. Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
    Title: Histone chaperone SSRP1 is required for apoptosis inhibition and mitochondrial function in HCC via transcriptional promotion of TRAP1.
  3. Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes.
    Title: Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes.
  4. Electron microscopy analysis of ATP-independent nucleosome unfolding by FACT.
    Title: Electron microscopy analysis of ATP-independent nucleosome unfolding by FACT.
  5. Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
    Title: Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG.
  6. Structural insights into multifunctionality of human FACT complex subunit hSSRP1.
    Title: Structural insights into multifunctionality of human FACT complex subunit hSSRP1.
  7. Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation.
    Title: Histone chaperone FACT complex inhibitor CBL0137 interferes with DNA damage repair and enhances sensitivity of medulloblastoma to chemotherapy and radiation.
  8. SSRP1 Is a Prognostic Biomarker Correlated with CD8(+) T Cell Infiltration in Hepatocellular Carcinoma (HCC).
    Title: SSRP1 Is a Prognostic Biomarker Correlated with CD8(+) T Cell Infiltration in Hepatocellular Carcinoma (HCC).
  9. CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.
    Title: CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC.
  10. The role of FACT in managing chromatin: disruption, assembly, or repair?
    Title: The role of FACT in managing chromatin: disruption, assembly, or repair?
Submit: New GeneRIF Correction See all GeneRIFs (54)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
HIV-1 infection requires SSRP1 as shown through shRNA-mediated knockdown of SSRP1 in human CD4+ T cells PubMed
shRNA knockdown of SSRP1 increases HIV-1 LTR-driven gene expression in HEK293 cells transduced with VSV-G pseudo-typed HIV-1 NL4-3-Luc construct; i.e. HIV-1 is restricted by SSRP1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The heterodimeric complex FACT proteins SPT16 and SSRP1 are recognized to interact with HIV-1 in Jurkat cell PubMed
tat HIV-1 Tat activated transcription facilitates removal of histones H2A and H2B at the LTR, and that the FACT complex, at least consisting of SPT16 and SSRP1, may be responsible for their removal PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in nucleosome disassembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromatin organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FACT complex subunit SSRP1
Names
FACT 80 kDa subunit
FACTp80
chromatin-specific transcription elongation factor 80 kDa subunit
cisplatin-DNA SSRP
facilitates chromatin remodeling 80 kDa subunit
facilitates chromatin transcription complex 80 kDa subunit
facilitates chromatin transcription complex subunit SSRP1
hSSRP1
high mobility group box
recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003146.3 → NP_003137.1  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_003137.1

    Status: REVIEWED

    Source sequence(s)
    AP000781
    Consensus CDS
    CCDS7952.1
    UniProtKB/Swiss-Prot
    Q08945, Q5BJG8
    Related
    ENSP00000278412.2, ENST00000278412.7
    Conserved Domains (2) summary
    COG5165
    Location:21 → 480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:547 → 614
    HMG_box; HMG (high mobility group) box

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    57325988..57335892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427498.1 → XP_047283454.1  FACT complex subunit SSRP1 isoform X2

    UniProtKB/Swiss-Prot
    Q08945, Q5BJG8

  2. XM_017018180.2 → XP_016873669.2  FACT complex subunit SSRP1 isoform X1

  3. XM_047427499.1 → XP_047283455.1  FACT complex subunit SSRP1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    57275479..57285383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369757.1 → XP_054225732.1  FACT complex subunit SSRP1 isoform X2

    UniProtKB/Swiss-Prot
    Q08945, Q5BJG8

  2. XM_054369756.1 → XP_054225731.1  FACT complex subunit SSRP1 isoform X1

  3. XM_054369758.1 → XP_054225733.1  FACT complex subunit SSRP1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08945.1 GenPept UniProtKB/Swiss-Prot:Q08945

Gene LinkOut

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