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Saysd1 SAYSVFN motif domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 67509, updated on 27-Nov-2024

Summary

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Official Symbol
Saysd1provided by MGI
Official Full Name
SAYSVFN motif domain containing 1provided by MGI
Primary source
MGI:MGI:1914759
See related
Ensembl:ENSMUSG00000045107 AllianceGenome:MGI:1914759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810063B07Rik; 4930488P03Rik
Summary
Predicted to enable UFM1-modified protein reader activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Is active in endoplasmic reticulum. Orthologous to human SAYSD1 (SAYSVFN motif domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 87.7), colon adult (RPKM 6.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Saysd1 in Genome Data Viewer
Location:
14 11.4 cM; 14 A3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20125704..20133240, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20075636..20083172, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 14, ERATO Doi 670, expressed Neighboring gene STARR-seq mESC enhancer starr_36086 Neighboring gene guanine nucleotide binding protein (G protein), gamma 2 Neighboring gene STARR-seq mESC enhancer starr_36089 Neighboring gene VISTA enhancer mm1498 Neighboring gene STARR-seq mESC enhancer starr_36096 Neighboring gene STARR-seq mESC enhancer starr_36097 Neighboring gene STARR-seq mESC enhancer starr_36099 Neighboring gene predicted gene, 41104 Neighboring gene predicted gene, 52125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice. Chang L, et al. Biochem Biophys Res Commun, 2023 Sep 24. PMID 37419030
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
    Title: The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UFM1-modified protein reader activity ISO
Inferred from Sequence Orthology
more info
  
enables UFM1-modified protein reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SAYSvFN domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026209.1 → NP_080485.1  SAYSvFN domain-containing protein 1

    See identical proteins and their annotated locations for NP_080485.1

    Status: VALIDATED

    Source sequence(s)
    AK031748, BC027644, BY096351, CJ320425
    Consensus CDS
    CCDS49406.1
    UniProtKB/Swiss-Prot
    Q8K190
    Related
    ENSMUSP00000055382.5, ENSMUST00000059666.6
    Conserved Domains (1) summary
    pfam10260
    Location:113 → 165
    SAYSvFN; Uncharacterized conserved domain (SAYSvFN)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20125704..20133240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316166.3 → XP_017171655.1  SAYSvFN domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam10260
    Location:61 → 113
    SAYSvFN; Uncharacterized conserved domain (SAYSvFN)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K190.1 GenPept UniProtKB/Swiss-Prot:Q8K190

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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