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Mgat4c MGAT4 family, member C [ Mus musculus (house mouse) ]

Gene ID: 67569, updated on 27-Nov-2024

Summary

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Official Symbol
Mgat4cprovided by MGI
Official Full Name
MGAT4 family, member Cprovided by MGI
Primary source
MGI:MGI:1914819
See related
Ensembl:ENSMUSG00000019888 AllianceGenome:MGI:1914819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GntIVh; 9130411I17Rik
Summary
Predicted to enable acetylglucosaminyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in Golgi membrane. Orthologous to human MGAT4C (MGAT4 family member C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in large intestine adult (RPKM 3.5), colon adult (RPKM 2.8) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Mgat4c in Genome Data Viewer
Location:
10 D1; 10 52.92 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (101517348..102227712)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (101681487..102391851)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_27741 Neighboring gene predicted gene, 26278 Neighboring gene microRNA 3059 Neighboring gene STARR-seq mESC enhancer starr_27742 Neighboring gene STARR-seq mESC enhancer starr_27743 Neighboring gene STARR-seq mESC enhancer starr_27744 Neighboring gene STARR-seq mESC enhancer starr_27745 Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 9 Neighboring gene neurotensin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article
  2. Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification. Petitpré C, et al. Nat Commun, 2022 Jul 5. PMID 35790771, Free PMC Article
  3. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Names
N-acetylglucosaminyltransferase IVc
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc
gnT-IVc
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
NP_001155840.1
NP_001155841.1
NP_001192027.1
NP_080519.2
XP_006514065.1
XP_006514066.1
XP_006514067.1
XP_006514068.1
XP_011241840.1
XP_030101095.1
XP_030101096.1
XP_036011857.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162368.2 → NP_001155840.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    See identical proteins and their annotated locations for NP_001155840.1

    Status: VALIDATED

    Source sequence(s)
    AC133175, AC168058
    Consensus CDS
    CCDS24153.1
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Related
    ENSMUSP00000131551.2, ENSMUST00000163753.8
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  2. NM_001162369.2 → NP_001155841.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    See identical proteins and their annotated locations for NP_001155841.1

    Status: VALIDATED

    Source sequence(s)
    AC133175, AC168058
    Consensus CDS
    CCDS24153.1
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Related
    ENSMUSP00000020039.7, ENSMUST00000020039.13
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  3. NM_001205098.2 → NP_001192027.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    See identical proteins and their annotated locations for NP_001192027.1

    Status: VALIDATED

    Source sequence(s)
    AC153502, AC153932, AC168058
    Consensus CDS
    CCDS24153.1
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  4. NM_001429516.1 → NP_001416445.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    Status: VALIDATED

    Source sequence(s)
    AC133175, AC168058
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306

  5. NM_001429517.1 → NP_001416446.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    Status: VALIDATED

    Source sequence(s)
    AC153502, AC153932, AC168058
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306

  6. NM_026243.5 → NP_080519.2  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

    See identical proteins and their annotated locations for NP_080519.2

    Status: VALIDATED

    Source sequence(s)
    AC168058
    Consensus CDS
    CCDS24153.1
    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Related
    ENSMUSP00000114010.2, ENSMUST00000120748.2
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

RNA

  1. NR_190742.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153502, AC153932, AC160559

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    101517348..102227712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514002.1 → XP_006514065.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  2. XM_036155964.1 → XP_036011857.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  3. XM_006514003.1 → XP_006514066.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    See identical proteins and their annotated locations for XP_006514066.1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  4. XM_030245235.1 → XP_030101095.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  5. XM_006514005.3 → XP_006514068.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    See identical proteins and their annotated locations for XP_006514068.1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  6. XM_030245236.1 → XP_030101096.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  7. XM_011243538.4 → XP_011241840.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    See identical proteins and their annotated locations for XP_011241840.1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region

  8. XM_006514004.4 → XP_006514067.1  alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform X1

    See identical proteins and their annotated locations for XP_006514067.1

    UniProtKB/Swiss-Prot
    Q9D2X2, Q9D306
    Conserved Domains (1) summary
    pfam04666
    Location:64 → 330
    Glyco_transf_54; N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D306.1 GenPept UniProtKB/Swiss-Prot:Q9D306

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