Reg4 regenerating islet-derived family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Reg4provided by MGI
Official Full Name: regenerating islet-derived family, member 4provided by MGI
Primary source: MGI:MGI:1914959
See related: Ensembl:ENSMUSG00000027876 AllianceGenome:MGI:1914959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GISP; RELP; 2010002L15Rik
Summary: Predicted to enable heparin binding activity; mannan binding activity; and signaling receptor activity. Acts upstream of or within response to bacterium. Predicted to be located in cytoplasm and extracellular space. Is expressed in appendicular skeleton; axial skeleton; and midbrain ventricular layer. Orthologous to human REG4 (regenerating family member 4). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in colon adult (RPKM 46.3), large intestine adult (RPKM 32.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 42.73 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (98129454..98144064)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (98222138..98236748)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain.
Title: Reg4 protects against Salmonella infection-associated intestinal inflammation via adopting a calcium-dependent lectin-like domain.
Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes.
Title: Upregulation of Reg IV and Hgf mRNAs by Intermittent Hypoxia via Downregulation of microRNA-499 in Cardiomyocytes.
Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling.
Title: Reg4 regulates pancreatic regeneration following pancreatitis via modulating the Notch signaling.
Cardiomyocytes situated in close proximity to the infarcted region produce large amounts of Reg3b, Reg3g, and Reg4, thereby forming a chemokine gradient that might direct interstitial migration of MHCIIhi/Ly6Clo and MHC-IIlo/Ly6Clo macrophage subsets.
Title: Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction.
sorted Reg4(+) DCS cells promote organoid formation of single Lgr5(+) colon stem cells. DCS cells can be massively produced from Lgr5(+) colon stem cells in vitro by combined Notch inhibition and Wnt activation
Title: Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
data suggest that Reg4 may protect against acinar cell necrosis in experimental pancreatitis by enhancing the expression of Bcl-2 and Bcl-xL via activation of the EGFR/Akt signalling pathway.
Title: Reg4 protects against acinar cell necrosis in experimental pancreatitis.
Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies.
Title: Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.
reg4 is amplified in the early stages of pancreatic cancer development
Title: The reg4 gene, amplified in the early stages of pancreatic cancer development, is a promising therapeutic target.
Cloning and characterization of human REG4/RELP, in addition to cloning of mouse Reg4.
Title: RELP, a novel human REG-like protein with up-regulated expression in inflammatory and metaplastic gastrointestinal mucosa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables mannan binding	IBA Inferred from Biological aspect of Ancestor more info
enables mannan binding	IEA Inferred from Electronic Annotation more info
enables mannan binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: regenerating islet-derived protein 4

Names: REG-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026328.2 → NP_080604.2 regenerating islet-derived protein 4 precursor

See identical proteins and their annotated locations for NP_080604.2

Status: VALIDATED

Source sequence(s)

AC121771, AK162316

Consensus CDS

CCDS17661.1

UniProtKB/Swiss-Prot

Q3TS25, Q9D858, Q9D8G5

Related

ENSMUSP00000029469.5, ENSMUST00000029469.5

Conserved Domains (1) summary

cd03594
Location:29 → 155

CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

98129454..98144064

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319697.1 → XP_017175186.1 regenerating islet-derived protein 4 isoform X1

Conserved Domains (1) summary

cl02432
Location:29 → 109

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain