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Itgb3bp integrin beta 3 binding protein (beta3-endonexin) [ Mus musculus (house mouse) ]

Gene ID: 67733, updated on 27-Nov-2024

Summary

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Official Symbol
Itgb3bpprovided by MGI
Official Full Name
integrin beta 3 binding protein (beta3-endonexin)provided by MGI
Primary source
MGI:MGI:1914983
See related
Ensembl:ENSMUSG00000028549 AllianceGenome:MGI:1914983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENP-R; 4930471O16Rik
Summary
Acts upstream of or within negative regulation of epithelial cell apoptotic process and positive regulation of epithelial cell proliferation. Located in kinetochore. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 1.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Itgb3bp in Genome Data Viewer
Location:
4 C6; 4 45.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (99655643..99717403, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99767406..99829215, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10873 Neighboring gene forkhead box D3 Neighboring gene STARR-positive B cell enhancer ABC_E6192 Neighboring gene STARR-seq mESC enhancer starr_10875 Neighboring gene ALG6 alpha-1,3-glucosyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:99495752-99496005 Neighboring gene EF-hand calcium binding domain 7 Neighboring gene STARR-positive B cell enhancer ABC_E6193 Neighboring gene predicted gene, 26425 Neighboring gene phosphoglucomutase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Okumura K, et al. Cancer Sci, 2017 Nov. PMID 28795467, Free PMC Article
  2. Reduced beta3-endonexin levels are associated with enhanced urokinase-type plasminogen activator receptor expression in ApoE-/- mice. Besta F, et al. Thromb Res, 2004. PMID 15381392
  3. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
  4. Structural insights into human CCAN complex assembled onto DNA. Tian T, et al. Cell Discov, 2022 Sep 9. PMID 36085283, Free PMC Article
  5. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of inner kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein R
Names
nuclear receptor-interacting factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362974.1 → NP_001349903.1  centromere protein R isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK165072
    Conserved Domains (1) summary
    pfam06729
    Location:8 → 85
    CENP-R; Kinetochore component, CENP-R

  2. NM_001362975.1 → NP_001349904.1  centromere protein R isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX005053, BX324127
    Conserved Domains (1) summary
    pfam06729
    Location:8 → 84
    CENP-R; Kinetochore component, CENP-R

  3. NM_001362976.1 → NP_001349905.1  centromere protein R isoform 4

    Status: VALIDATED

    Source sequence(s)
    BX005053, BX324127
    Related
    ENSMUST00000102786.11
    Conserved Domains (1) summary
    pfam06729
    Location:1 → 77
    CENP-R; Kinetochore component, CENP-R

  4. NM_026348.4 → NP_080624.1  centromere protein R isoform 1

    See identical proteins and their annotated locations for NP_080624.1

    Status: VALIDATED

    Source sequence(s)
    AK045037, AK165072
    Consensus CDS
    CCDS18387.1
    UniProtKB/Swiss-Prot
    Q3TLR0, Q3TNR4, Q9CQ82
    Related
    ENSMUSP00000117153.2, ENSMUST00000146258.2
    Conserved Domains (1) summary
    pfam06729
    Location:25 → 161
    CENP-R; Kinetochore component, CENP-R

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    99655643..99717403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240600.4 → XP_011238902.1  centromere protein R isoform X1

    Conserved Domains (1) summary
    pfam06729
    Location:27 → 162
    CENP-R; Kinetochore component, CENP-R
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ82.1 GenPept UniProtKB/Swiss-Prot:Q9CQ82

Gene LinkOut

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