lyz lysozyme [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lyzprovided by ZNC
Official Full Name: lysozymeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020515-2
See related: Ensembl:ENSDARG00000057789 AllianceGenome:ZFIN:ZDB-GENE-020515-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lys-C; zgc:136734
Summary: Predicted to enable lysozyme activity. Involved in cell maturation. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; pleuroperitoneal region; and posterior cardinal vein. Orthologous to several human genes including LYZL1 (lysozyme like 1) and LYZL2 (lysozyme like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (24035863..24038783, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (23890689..23893609, complement)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows for the first time that beta-glucan can enhance the C-type lysozyme level in offspring via both inducing the transfer of the molecule from mothers to eggs and stimulating its endogenous production in oocytes
Title: Trans-generational enhancement of C-type lysozyme level in eggs of zebrafish by dietary β-glucan.
C/ebp1 and runx1 presumably cooperated with pu.1 in the transcriptional regulation of lyz during zebrafish myelopoiesis.
Title: Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesis.
Molecular cloning and expression of lysozyme C [lysozyme C]
Title: Cloning and expression pattern of the lysozyme C gene in zebrafish.
regulatory regions of the zebrafish lysozyme C (lysC) gene drive enhanced green fluorescent protein (EGFP) and DsRED2 expression in a manner that completely recapitulated the endogenous expression profile of lysC
Title: The zebrafish lysozyme C promoter drives myeloid-specific expression in transgenic fish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysozyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell maturation	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: lysozyme C

Names: lys C

NP_631919.1

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139180.1 → NP_631919.1 lysozyme C precursor

See identical proteins and their annotated locations for NP_631919.1

Status: PROVISIONAL

Source sequence(s)

AF402599

UniProtKB/TrEMBL

Q90YS5

Related

ENSDARP00000074998.3, ENSDART00000080549.4

Conserved Domains (1) summary

cd00119
Location:19 → 140

LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...