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Limd2 LIM domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 67803, updated on 27-Nov-2024

Summary

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Official Symbol
Limd2provided by MGI
Official Full Name
LIM domain containing 2provided by MGI
Primary source
MGI:MGI:1915053
See related
Ensembl:ENSMUSG00000040699 AllianceGenome:MGI:1915053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610025L06Rik
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in actin cytoskeleton and plasma membrane. Is expressed in central nervous system; foregut; genitourinary system; and sensory organ. Orthologous to human LIMD2 (LIM domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 154.4), thymus adult (RPKM 102.1) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Limd2 in Genome Data Viewer
Location:
11 E1; 11 68.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106047080..106051555, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106156254..106160729, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene STARR-positive B cell enhancer ABC_E2372 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I Neighboring gene STARR-positive B cell enhancer ABC_E258 Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene STE20-related kinase adaptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene coiled-coil domain containing 47

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The genetic program of hematopoietic stem cells. Phillips RL, et al. Science, 2000 Jun 2. PMID 10834841
  2. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article
  3. LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow. Tseng HY, et al. J Cell Sci, 2018 Nov 21. PMID 30333137, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LIM domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356458.1 → NP_001343387.1  LIM domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL596331, BC068130, CF738656
    Consensus CDS
    CCDS25549.1
    UniProtKB/Swiss-Prot
    Q8BGB5
    Related
    ENSMUSP00000102488.2, ENSMUST00000106875.2
    Conserved Domains (1) summary
    cd09486
    Location:41 → 93
    LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

  2. NM_001356459.1 → NP_001343388.1  LIM domain-containing protein 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC068130, BU697882, BY078132, CF738656
    Consensus CDS
    CCDS25549.1
    UniProtKB/Swiss-Prot
    Q8BGB5
    Related
    ENSMUSP00000067070.5, ENSMUST00000064545.11
    Conserved Domains (1) summary
    cd09486
    Location:41 → 93
    LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

  3. NM_172397.4 → NP_765985.1  LIM domain-containing protein 2

    See identical proteins and their annotated locations for NP_765985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AL596331, BC068130, CF738656
    Consensus CDS
    CCDS25549.1
    UniProtKB/Swiss-Prot
    Q8BGB5
    Related
    ENSMUSP00000045357.4, ENSMUST00000045923.10
    Conserved Domains (1) summary
    cd09486
    Location:41 → 93
    LIM_Eplin_like_1; a LIM domain subfamily on a group of proteins with unknown function

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106047080..106051555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGB5.1 GenPept UniProtKB/Swiss-Prot:Q8BGB5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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