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Atp1b4 ATPase Na+/K+ transporting, beta 4 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 67821, updated on 27-Nov-2024

Summary

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Official Symbol
Atp1b4provided by MGI
Official Full Name
ATPase Na+/K+ transporting, beta 4 polypeptideprovided by MGI
Primary source
MGI:MGI:1915071
See related
Ensembl:ENSMUSG00000016327 AllianceGenome:MGI:1915071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110020B02Rik
Summary
Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in alimentary system; axial skeleton; musculature; and tongue. Orthologous to human ATP1B4 (ATPase Na+/K+ transporting family member beta 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 1.7), CNS E18 (RPKM 0.6) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Atp1b4 in Genome Data Viewer
Location:
X A3.3; X 22.58 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (37404999..37425661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (38316122..38336784)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene arylsulfatase K pseudogene Neighboring gene reproductive homeobox 7, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_47016 Neighboring gene predicted pseudogene 40 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes. Zhao H, et al. Am J Physiol Cell Physiol, 2004 Apr. PMID 14656723
  2. Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals. Pestov NB, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592128, Free PMC Article
  3. Evolutionary diversification of the BetaM interactome acquired through co-option of the ATP1B4 gene in placental mammals. Korneenko TV, et al. Sci Rep, 2016 Mar 4. PMID 26939788, Free PMC Article
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During evolution, ATP1B4 lost its ancestral function, accumulated in nuclear membrane of perinatal myocytes, and associates with transcriptional coregulator Ski-interacting protein (SKIP).
    Title: Evolution of Na,K-ATPase beta m-subunit into a coregulator of transcription in placental mammals.
  2. primary structure was determined and developmental regulation of the gene (ATP1B4) was analyzed
    Title: Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in inorganic cation transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of sodium:potassium-exchanging ATPase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ATP1B4
Names
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
x,K-ATPase subunit beta-m
x/potassium-transporting ATPase subunit beta-m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290389.1 → NP_001277318.1  protein ATP1B4 isoform 2

    See identical proteins and their annotated locations for NP_001277318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK003843, AK053500, AV247095, BY771893
    Consensus CDS
    CCDS72368.1
    UniProtKB/TrEMBL
    B1APX1
    Related
    ENSMUSP00000110787.2, ENSMUST00000115134.2
    Conserved Domains (1) summary
    pfam00287
    Location:84 → 345
    Na_K-ATPase; Sodium / potassium ATPase beta chain

  2. NM_133690.3 → NP_598451.1  protein ATP1B4 isoform 1

    See identical proteins and their annotated locations for NP_598451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK003843, AK053500, AV247095, BY771893
    Consensus CDS
    CCDS30090.1
    UniProtKB/Swiss-Prot
    Q543D0, Q99ME5, Q99ME6
    Related
    ENSMUSP00000016471.3, ENSMUST00000016471.9
    Conserved Domains (1) summary
    pfam00287
    Location:84 → 349
    Na_K-ATPase; Sodium / potassium ATPase beta chain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    37404999..37425661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541533.1 → XP_006541596.1  protein ATP1B4 isoform X1

    Conserved Domains (1) summary
    pfam00287
    Location:2 → 217
    Na_K-ATPase; Sodium / potassium ATPase beta chain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99ME6.1 GenPept UniProtKB/Swiss-Prot:Q99ME6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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