Ccdc80 coiled-coil domain containing 80 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccdc80provided by MGI
Official Full Name: coiled-coil domain containing 80provided by MGI
Primary source: MGI:MGI:1915146
See related: Ensembl:ENSMUSG00000022665 AllianceGenome:MGI:1915146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Urb; DRO1; Ssg1; 2610001E17Rik
Summary: Enables fibronectin binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization; positive regulation of cell-substrate adhesion; and response to bacterium. Located in basement membrane and interstitial matrix. Is expressed in several structures, including alimentary system; brain; cardiovascular system; limb cartilage condensation; and musculoskeletal system. Orthologous to human CCDC80 (coiled-coil domain containing 80). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 96.6), mammary gland adult (RPKM 61.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 29.39 cM; 16 B5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (44913770..44948287)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45093407..45127924)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we showed that CCDC80 inhibited ERK1/2 activation, decreased TET2 expression and TET2-mediated DNA demethylation, and then promoted DNA methylation of the LPL gene. Consequently, CCDC80 reduced LPL expression and activity, leading to increased plasma TG levels and enhanced atherosclerotic lesions area, which at least partially involved FOXO3a.
Title: Coiled-coil domain-containing 80 accelerates atherosclerosis development through decreasing lipoprotein lipase expression via ERK1/2 phosphorylation and TET2 expression.
The results demonstrate DRO1 to be a strong tumor suppressor in the chemically induced colon carcinogenic mouse model. Additionally, DRO1 inhibits colitis-associated colon cancer formation and plays a putative role for in inflammatory bowel disease.
Title: Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.
DRO1 is a crucial regulator of energy homeostasis in vivo and functions as an inhibitor of adipogenesis in primary cells.
Title: Loss of DRO1/CCDC80 results in obesity and promotes adipocyte differentiation.
This report characterizes a new mouse model for the study of colorectal cancer and establishes DRO1 (CCDC80) as a tumor suppressor via a mechanism involving ERK phosphorylation.
Title: DRO1 inactivation drives colorectal carcinogenesis in ApcMin/+ mice.
Ccdc80 is a novel betacat-regulated gene in adrenocortical cells
Title: Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
Data indicate that embryonic fibroblasts from cl2/coiled-coil domain-containing protein 80 (ccdc80) knock-out mice showed higher proliferation rate and lower susceptibility to apoptosis.
Title: The cl2/dro1/ccdc80 null mice develop thyroid and ovarian neoplasias.
Results suggest that Ccdc80 is a novel modulator of glucose and energy homeostasis during diet-induced obesity.
Title: Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.
Ccdc80 plays dual roles in adipogenesis by mechanisms that involve at least in part down-regulation of Wnt/beta-catenin signaling and induction of C/EBPalpha and peroxisome proliferator-activated receptor gamma.
Title: Bidirectional modulation of adipogenesis by the secreted protein Ccdc80/DRO1/URB.
In conclusion, the expression pattern of URB suggests its role in obesity and the results suggest that URB is secreted, at least in part, from adipocytes.
Title: URB is abundantly expressed in adipose tissue and dysregulated in obesity.
Downregulated during osteoblastic differentiation of bone marrow stromal cells. Suggests role in skeletogenesis.
Title: URB expression in human bone marrow stromal cells and during mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1S3691 (e-PCR)
- UniSTS:474269

Ssg1-pending (e-PCR), detects polymorphism
- UniSTS:256453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coiled-coil domain-containing protein 80

Names: steroid sensitive gene 1; up-regulated in BRS-3 deficient mouse

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.