Arhgap19 Rho GTPase activating protein 19 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap19provided by RGD
Official Full Name: Rho GTPase activating protein 19provided by RGD
Primary source: RGD:1593044
See related: EnsemblRapid:ENSRNOG00000048166 AllianceGenome:RGD:1593044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 72.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250519703..250566705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (240571554..240617361, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261015083..261051515, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of small GTPase mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rho GTPase-activating protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401120.1 → NP_001388049.1 rho GTPase-activating protein 19

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

M0R5V4

Related

ENSRNOP00000064785.2, ENSRNOT00000071417.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

250519703..250566705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101420.2 → XP_038957348.1 rho GTPase-activating protein 19 isoform X5

Conserved Domains (1) summary

cd04392
Location:18 → 225

RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
XM_039101419.2 → XP_038957347.1 rho GTPase-activating protein 19 isoform X1

UniProtKB/TrEMBL

A0A8I6ACN1

Conserved Domains (1) summary

cd04392
Location:113 → 320

RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
XM_063273204.1 → XP_063129274.1 rho GTPase-activating protein 19 isoform X4
XM_063273199.1 → XP_063129269.1 rho GTPase-activating protein 19 isoform X3

Related

ENSRNOP00000089901.2, ENSRNOT00000097202.2
XM_017590380.2 → XP_017445869.1 rho GTPase-activating protein 19 isoform X3

UniProtKB/TrEMBL

A0A8I6ACN1
XM_063273187.1 → XP_063129257.1 rho GTPase-activating protein 19 isoform X2

Related

ENSRNOP00000112280.1, ENSRNOT00000152733.1