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Mettl1 methyltransferase 1, tRNA methylguanosine [ Rattus norvegicus (Norway rat) ]

Gene ID: 679091, updated on 27-Nov-2024

Summary

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Official Symbol
Mettl1provided by RGD
Official Full Name
methyltransferase 1, tRNA methylguanosineprovided by RGD
Primary source
RGD:1593036
See related
EnsemblRapid:ENSRNOG00000047895 AllianceGenome:RGD:1593036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 39.1), Kidney (RPKM 33.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mettl1 in Genome Data Viewer
Location:
7q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64750189..64754531)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62864860..62869202)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70328470..70333045)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene advillin Neighboring gene Ts translation elongation factor, mitochondrial Neighboring gene EEF1A lysine methyltransferase 3 Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene membrane associated ring-CH-type finger 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells. Cartlidge RA, et al. EMBO J, 2005 May 4. PMID 15861136, Free PMC Article
  2. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. Alexandrov A, et al. RNA, 2002 Oct. PMID 12403464, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables internal mRNA (guanine-N7-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA (guanine(46)-N7)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (guanine(46)-N7)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA (guanine-N7)-methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA (guanine-N7)-methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of tRNA (m7G46) methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of tRNA methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tRNA (guanine-N(7)-)-methyltransferase
Names
methyltransferase like 1
NP_001385862.1
NP_001385863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398933.1 → NP_001385862.1  tRNA (guanine-N(7)-)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A6HQR6
    Related
    ENSRNOP00000064874.3, ENSRNOT00000075544.4
    Conserved Domains (1) summary
    pfam02390
    Location:70 → 247
    Methyltransf_4; Putative methyltransferase

  2. NM_001398934.1 → NP_001385863.1  tRNA (guanine-N(7)-)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    Related
    ENSRNOP00000093899.1, ENSRNOT00000117922.2
    Conserved Domains (1) summary
    pfam02390
    Location:34 → 211
    Methyltransf_4; Putative methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    64750189..64754531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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