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Ube2f ubiquitin-conjugating enzyme E2F (putative) [ Mus musculus (house mouse) ]

Gene ID: 67921, updated on 27-Nov-2024

Summary

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Official Symbol
Ube2fprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2F (putative)provided by MGI
Primary source
MGI:MGI:1915171
See related
Ensembl:ENSMUSG00000034343 AllianceGenome:MGI:1915171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2510010F15Rik
Summary
Enables NEDD8 transferase activity. Involved in protein neddylation. Predicted to be active in cytosol and nucleus. Orthologous to human UBE2F (ubiquitin conjugating enzyme E2 F (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 22.6), placenta adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ube2f in Genome Data Viewer
Location:
1 D; 1 46.08 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91177412..91214243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91249690..91286521)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93080001-93080198 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93089975-93090287 Neighboring gene receptor (calcitonin) activity modifying protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9471 Neighboring gene STARR-positive B cell enhancer ABC_E498 Neighboring gene STARR-positive B cell enhancer ABC_E794 Neighboring gene zinc finger protein 330 pseudogene Neighboring gene selenocysteine lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ube2m-Rbx1 neddylation-Cullin-RING-Ligase proteins are essential for the maintenance of Regulatory T cell fitness. Wu D, et al. Nat Commun, 2022 May 31. PMID 35641500, Free PMC Article
  2. The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Chang Y, et al. Dev Cell, 2024 May 20. PMID 38574733
  3. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Huang DT, et al. Mol Cell, 2009 Feb 27. PMID 19250909, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables NEDD8 transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NEDD8 transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NEDD8 transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein neddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein neddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEDD8-conjugating enzyme UBE2F
Names
NEDD8 carrier protein UBE2F
NEDD8 protein ligase UBE2F
NEDD8-conjugating enzyme 2
RING-type E3 NEDD8 transferase UBE2F
ubiquitin-conjugating enzyme E2 F
NP_001342690.1
NP_001342691.1
NP_001342692.1
NP_001342693.1
NP_080730.1
XP_006529901.1
XP_011246369.1
XP_017177752.1
XP_030098417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355761.1 → NP_001342690.1  NEDD8-conjugating enzyme UBE2F

    Status: VALIDATED

    Source sequence(s)
    AC102874, AK010957, AK030594, BB621519, BQ032120
    Consensus CDS
    CCDS48322.1
    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Related
    ENSMUSP00000054303.6, ENSMUST00000059743.12
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_001355762.1 → NP_001342691.1  NEDD8-conjugating enzyme UBE2F

    Status: VALIDATED

    Source sequence(s)
    AK030594, BB621519, BQ032120
    Consensus CDS
    CCDS48322.1
    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Related
    ENSMUSP00000126173.2, ENSMUST00000171165.8
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_001355763.1 → NP_001342692.1  NEDD8-conjugating enzyme UBE2F

    Status: VALIDATED

    Source sequence(s)
    AC102874, AK007937, BB621519, BQ032120, CO430243
    Consensus CDS
    CCDS48322.1
    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Related
    ENSMUSP00000140743.2, ENSMUST00000191368.7
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_001355764.1 → NP_001342693.1  NEDD8-conjugating enzyme UBE2F

    Status: VALIDATED

    Source sequence(s)
    AC102874
    Consensus CDS
    CCDS48322.1
    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Related
    ENSMUSP00000131330.2, ENSMUST00000171112.8
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  5. NM_026454.4 → NP_080730.1  NEDD8-conjugating enzyme UBE2F

    See identical proteins and their annotated locations for NP_080730.1

    Status: VALIDATED

    Source sequence(s)
    AK030594, AK153481, BB621519, BQ032120
    Consensus CDS
    CCDS48322.1
    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Related
    ENSMUSP00000136915.2, ENSMUST00000178627.8
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. NR_149825.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK030594, BB621519, BQ032120, CX219989

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91177412..91214243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322263.1 → XP_017177752.1  NEDD8-conjugating enzyme UBE2F isoform X1

    Conserved Domains (1) summary
    cl00154
    Location:63 → 207
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. XM_011248067.3 → XP_011246369.1  NEDD8-conjugating enzyme UBE2F isoform X2

    See identical proteins and their annotated locations for XP_011246369.1

    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. XM_006529838.5 → XP_006529901.1  NEDD8-conjugating enzyme UBE2F isoform X2

    See identical proteins and their annotated locations for XP_006529901.1

    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. XM_030242557.2 → XP_030098417.1  NEDD8-conjugating enzyme UBE2F isoform X2

    UniProtKB/Swiss-Prot
    Q3UWQ3, Q99JK3, Q9CY34, Q9D8K0, Q9D8K7
    Conserved Domains (1) summary
    cl00154
    Location:30 → 184
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY34.1 GenPept UniProtKB/Swiss-Prot:Q9CY34

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