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Tmem131l transmembrane 131 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 679811, updated on 4-Jan-2025

Summary

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Official Symbol
Tmem131lprovided by RGD
Official Full Name
transmembrane 131 likeprovided by RGD
Primary source
RGD:1583677
See related
EnsemblRapid:ENSRNOG00000009837 AllianceGenome:RGD:1583677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305449
Summary
Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human TMEM131L (transmembrane 131 like). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 231.7), Spleen (RPKM 217.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem131l in Genome Data Viewer
Location:
2q34
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (171555673..171689774, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (169257659..169391773, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (182897332..183031273, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene toll-like receptor 2 Neighboring gene uncharacterized LOC134485932 Neighboring gene uncharacterized LOC134485933 Neighboring gene peflin pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. Maharzi N, et al. J Immunol, 2013 Jun 15. PMID 23690469
  2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 131-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399524.1 → NP_001386453.1  transmembrane protein 131-like isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    D3ZRG1
    Related
    ENSRNOP00000013260.6, ENSRNOT00000013260.9
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  2. NM_001399525.1 → NP_001386454.1  transmembrane protein 131-like isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    171555673..171689774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282520.1 → XP_063138590.1  transmembrane protein 131-like isoform X5

  2. XM_006232547.4 → XP_006232609.1  transmembrane protein 131-like isoform X1

    See identical proteins and their annotated locations for XP_006232609.1

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  3. XM_008761116.4 → XP_008759338.1  transmembrane protein 131-like isoform X4

    See identical proteins and their annotated locations for XP_008759338.1

    UniProtKB/TrEMBL
    A0A8I6AV47
    Related
    ENSRNOP00000097919.1, ENSRNOT00000115508.2
    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  4. XM_039103734.2 → XP_038959662.1  transmembrane protein 131-like isoform X2

    Conserved Domains (1) summary
    cl13764
    Location:91 → 174
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  5. XM_063282521.1 → XP_063138591.1  transmembrane protein 131-like isoform X7

  6. XM_006232549.5 → XP_006232611.1  transmembrane protein 131-like isoform X3

    See identical proteins and their annotated locations for XP_006232611.1

    Conserved Domains (1) summary
    cl13764
    Location:55 → 138
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

  7. XM_006232550.4 → XP_006232612.1  transmembrane protein 131-like isoform X6

    See identical proteins and their annotated locations for XP_006232612.1

    Conserved Domains (1) summary
    cl13764
    Location:20 → 103
    ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

RNA

  1. XR_005501038.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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