Nacc2 nucleus accumbens associated 2, BEN and BTB (POZ) domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nacc2provided by MGI
Official Full Name: nucleus accumbens associated 2, BEN and BTB (POZ) domain containingprovided by MGI
Primary source: MGI:MGI:1915241
See related: Ensembl:ENSMUSG00000026932 AllianceGenome:MGI:1915241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Btbd14a; 0610020I02Rik; C030048H19Rik
Summary: Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Predicted to be located in chromatin; mitochondrion; and nucleolus. Is expressed in several structures, including brain; limb; renal calyx; submandibular gland primordium; and tooth. Orthologous to human NACC2 (NACC family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 26.3), bladder adult (RPKM 17.2) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 18.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25945547..26012823, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26055535..26122811, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleus accumbens-associated protein 2

Names: BTB (POZ) domain containing 14A; BTB/POZ domain-containing protein 14A; NAC-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037098.1 → NP_001032175.1 nucleus accumbens-associated protein 2

See identical proteins and their annotated locations for NP_001032175.1

Status: VALIDATED

Source sequence(s)

AK147293, AK147310, BE983327, CN668689

Consensus CDS

CCDS15796.1

UniProtKB/Swiss-Prot

Q3TZD3, Q8VDF8, Q9DCM7

Related

ENSMUSP00000109796.3, ENSMUST00000114159.9

Conserved Domains (3) summary

smart01025
Location:371 → 448

BEN; The BEN domain is found in diverse animal proteins

cd18289
Location:1 → 131

BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)

pfam02161
Location:139 → 241

Prog_receptor; Progesterone receptor
NM_026495.3 → NP_080771.3 nucleus accumbens-associated protein 2

See identical proteins and their annotated locations for NP_080771.3

Status: VALIDATED

Source sequence(s)

AK147293, CN668689

Consensus CDS

CCDS15796.1

UniProtKB/Swiss-Prot

Q3TZD3, Q8VDF8, Q9DCM7

Related

ENSMUSP00000028300.6, ENSMUST00000028300.6

Conserved Domains (3) summary

smart01025
Location:371 → 448

BEN; The BEN domain is found in diverse animal proteins

cd18289
Location:1 → 131

BTB_POZ_BTBD14A_NAC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2)

pfam02161
Location:139 → 241

Prog_receptor; Progesterone receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

25945547..26012823 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498260.1 → XP_006498323.1 nucleus accumbens-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_006498323.1

Conserved Domains (3) summary

smart01025
Location:344 → 421

BEN; The BEN domain is found in diverse animal proteins

cl38908
Location:1 → 104

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam02161
Location:112 → 214

Prog_receptor; Progesterone receptor
XM_006498259.1 → XP_006498322.1 nucleus accumbens-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_006498322.1

Conserved Domains (3) summary

smart01025
Location:344 → 421

BEN; The BEN domain is found in diverse animal proteins

cl38908
Location:1 → 104

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam02161
Location:112 → 214

Prog_receptor; Progesterone receptor