Angptl1 angiopoietin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Angptl1provided by RGD
Official Full Name: angiopoietin-like 1provided by RGD
Primary source: RGD:1598128
See related: EnsemblRapid:ENSRNOG00000004712 AllianceGenome:RGD:1598128
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL1 (angiopoietin like 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 201.9), Muscle (RPKM 197.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (71463913..71531810)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (68963186..68981649)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (74456487..74463031)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

No gross E2 effect on the ependymal pattern of Angpt1 or cerebral Angpt1 protein content is observed.
Title: Localization of angiopoietin-1 and Tie2 immunoreactivity in rodent ependyma and adjacent blood vessels suggests functional relationships.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402356.1 → NP_001389285.1 angiopoietin-related protein 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A0G2K603, A6ID22, D4A593

Related

ENSRNOP00000073625.1, ENSRNOT00000079152.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

71463913..71531810

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272599.1 → XP_063128669.1 angiopoietin-related protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K603, A6ID22, D4A593

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001109383.1: Suppressed sequence

Description

NM_001109383.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.