Tirap TIR domain containing adaptor protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tirapprovided by RGD
Official Full Name: TIR domain containing adaptor proteinprovided by RGD
Primary source: RGD:1595496
See related: EnsemblRapid:ENSRNOG00000021420 AllianceGenome:RGD:1595496
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including TIRAP-dependent toll-like receptor 4 signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including myeloid cell differentiation; positive regulation of macrophage cytokine production; and response to bacterium. Predicted to be located in endocytic vesicle and ruffle membrane. Predicted to be active in cell surface; cytoplasm; and plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 48.7), Spleen (RPKM 47.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (41789557..41805903, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33531724..33548508, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36382029..36399625, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Toll-like receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables Toll-like receptor 4 binding	IBA Inferred from Biological aspect of Ancestor more info
enables Toll-like receptor 4 binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in 3'-UTR-mediated mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in TIRAP-dependent toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
NOT involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-15 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-15 production	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor 4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in toll-like receptor 5 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
NOT located_in peroxisome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll/interleukin-1 receptor domain-containing adapter protein

Names: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430386.1 → NP_001417315.1 toll/interleukin-1 receptor domain-containing adapter protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYJ6, D3ZXA5
NM_001430387.1 → NP_001417316.1 toll/interleukin-1 receptor domain-containing adapter protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6JYJ6, D3ZXA5

RNA

NR_190896.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

41789557..41805903 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017596003.3 → XP_017451492.1 toll/interleukin-1 receptor domain-containing adapter protein

UniProtKB/TrEMBL

A6JYJ6, D3ZXA5

Related

ENSRNOP00000032025.5, ENSRNOT00000038312.7

Conserved Domains (1) summary

pfam13676
Location:117 → 232

TIR_2; TIR domain