Nutf2 nuclear transport factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nutf2provided by MGI
Official Full Name: nuclear transport factor 2provided by MGI
Primary source: MGI:MGI:1915301
See related: Ensembl:ENSMUSG00000008450 AllianceGenome:MGI:1915301
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ntf2; Ntf3; PP15; 2700067I02Rik
Summary: Predicted to enable identical protein binding activity; nuclear import signal receptor activity; and small GTPase binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol; nuclear outer membrane; and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; integumental system; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 42.8), CNS E14 (RPKM 34.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.05 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106587165..106607034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105860533..105880402)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Thap11 (e-PCR), detects polymorphism
- UniSTS:525624

AI413596 (e-PCR)
- UniSTS:159803

AW546000 (e-PCR)
- UniSTS:181067

NUTF2_9060 (e-PCR)
- UniSTS:468096

RH135867 (e-PCR)
- UniSTS:209865

UniSTS:235986 (e-PCR)
- UniSTS:235986

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleocytoplasmic carrier activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nuclear pore	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore central transport channel	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear transport factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357229.1 → NP_001344158.1 nuclear transport factor 2

Status: VALIDATED

Source sequence(s)

AC116569, AC159265

Consensus CDS

CCDS22617.1

UniProtKB/Swiss-Prot

P61971, Q3TI35

UniProtKB/TrEMBL

Q3U8H8

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001357230.1 → NP_001344159.1 nuclear transport factor 2

Status: VALIDATED

Source sequence(s)

AC116569, AC159265

Consensus CDS

CCDS22617.1

UniProtKB/Swiss-Prot

P61971, Q3TI35

UniProtKB/TrEMBL

Q3U8H8

Related

ENSMUSP00000148713.2, ENSMUST00000212042.2

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_026532.4 → NP_080808.1 nuclear transport factor 2

See identical proteins and their annotated locations for NP_080808.1

Status: VALIDATED

Source sequence(s)

AK002461, BC086773, CJ059612

Consensus CDS

CCDS22617.1

UniProtKB/Swiss-Prot

P61971, Q3TI35

UniProtKB/TrEMBL

Q3U8H8

Related

ENSMUSP00000008594.8, ENSMUST00000008594.9

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...