Sem1 SEM1 26S proteasome subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sem1provided by RGD
Official Full Name: SEM1 26S proteasome subunitprovided by RGD
Primary source: RGD:1590628
See related: EnsemblRapid:ENSRNOG00000010420 AllianceGenome:RGD:1590628
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dss1; Shfm1
Summary: Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be part of integrator complex and proteasome complex. Orthologous to human SEM1 (SEM1 26S proteasome subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 695.2), Muscle (RPKM 631.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (35638306..35658462, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (34671848..34692005, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (32067444..32087600, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif.
Title: BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
analysis of proteasome 19 and 26 dysfunction after brain ischemia
Title: Protein aggregation and proteasome dysfunction after brain ischemia.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in proteasome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of integrator complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, lid subcomplex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 26S proteasome complex subunit SEM1

Names: 26S proteasome complex subunit DSS1; SEM1, 26S proteasome complex subunit; split hand/foot malformation (ectrodactyly) type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.