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Ppp1r16b protein phosphatase 1, regulatory subunit 16B [ Rattus norvegicus (Norway rat) ]

Gene ID: 680616, updated on 4-Jan-2025

Summary

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Official Symbol
Ppp1r16bprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 16Bprovided by RGD
Primary source
RGD:1589460
See related
EnsemblRapid:ENSRNOG00000015614 AllianceGenome:RGD:1589460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Predicted to be involved in several processes, including establishment of endothelial barrier; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in several cellular components, including nuclear speck; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 121.7), Brain (RPKM 72.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r16b in Genome Data Viewer
Location:
3q42
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (167743518..167839511)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (147323652..147419658)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (155160474..155267002)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 32 member 1 Neighboring gene actin related protein 5 Neighboring gene 60S ribosomal protein L13-like Neighboring gene family with sequence similarity 83, member D Neighboring gene DEAH-box helicase 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TIMAP protects endothelial barrier from LPS-induced vascular leakage and is down-regulated by LPS. Poirier C, et al. Respir Physiol Neurobiol, 2011 Dec 15. PMID 21907835, Free PMC Article
  2. Characterization of the effect of TIMAP phosphorylation on its interaction with protein phosphatase 1. Czikora I, et al. Biochimie, 2011 Jul. PMID 21466834, Free PMC Article
  3. Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. Boratkó A, et al. Int J Biochem Cell Biol, 2015 Dec. PMID 26497934
  4. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. Obeidat M, et al. Am J Physiol Renal Physiol, 2014 Sep 1. PMID 25007873
  5. TIMAP is a positive regulator of pulmonary endothelial barrier function. Csortos C, et al. Am J Physiol Lung Cell Mol Physiol, 2008 Sep. PMID 18586956, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in establishment of endothelial barrier IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of sprouting angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory inhibitor subunit 16B
Names
protein phosphatase 1, regulatory (inhibitor) subunit 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191072.1 → NP_001178001.1  protein phosphatase 1 regulatory inhibitor subunit 16B

    See identical proteins and their annotated locations for NP_001178001.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    D4AA72
    Related
    ENSRNOP00000021133.4, ENSRNOT00000021133.9
    Conserved Domains (3) summary
    PHA03095
    Location:71 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:71 → 98
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:72 → 164
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    167743518..167839511
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762383.4 → XP_008760605.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

    See identical proteins and their annotated locations for XP_008760605.1

    UniProtKB/TrEMBL
    D4AA72
    Conserved Domains (3) summary
    PHA03095
    Location:71 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:71 → 98
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:72 → 164
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_017592039.3 → XP_017447528.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X2

  3. XM_008762384.3 → XP_008760606.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

    See identical proteins and their annotated locations for XP_008760606.1

    UniProtKB/TrEMBL
    D4AA72
    Conserved Domains (3) summary
    PHA03095
    Location:71 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:71 → 98
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:72 → 164
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039105844.2 → XP_038961772.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

    UniProtKB/TrEMBL
    D4AA72
    Conserved Domains (3) summary
    PHA03095
    Location:71 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:71 → 98
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:72 → 164
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_008762385.3 → XP_008760607.1  protein phosphatase 1 regulatory inhibitor subunit 16B isoform X1

    See identical proteins and their annotated locations for XP_008760607.1

    UniProtKB/TrEMBL
    D4AA72
    Conserved Domains (3) summary
    PHA03095
    Location:71 → 301
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:71 → 98
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:72 → 164
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version

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