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Spcs3 signal peptidase complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680782, updated on 9-Dec-2024

Summary

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Official Symbol
Spcs3provided by RGD
Official Full Name
signal peptidase complex subunit 3provided by RGD
Primary source
RGD:1588184
See related
EnsemblRapid:ENSRNOG00000038933 AllianceGenome:RGD:1588184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Liver (RPKM 618.0), Spleen (RPKM 374.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Spcs3 in Genome Data Viewer
Location:
16p11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (44038421..44043855)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (37305358..37310792)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (40050862..40056296)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 4 Neighboring gene ankyrin repeat and SOCS box-containing 5 Neighboring gene U6 spliceosomal RNA Neighboring gene pancreatic progenitor cell differentiation and proliferation factor-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix. Chen Q, et al. Mol Cell, 2016 Aug 18. PMID 27499293, Free PMC Article
  2. Membrane topology and biogenesis of eukaryotic signal peptidase. Shelness GS, et al. J Biol Chem, 1993 Mar 5. PMID 8444896
  3. Purification of microsomal signal peptidase as a complex. Evans EA, et al. Proc Natl Acad Sci U S A, 1986 Feb. PMID 3511473, Free PMC Article
  4. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Zhang R, et al. Nature, 2016 Jul 7. PMID 27383988, Free PMC Article
  5. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies KU, et al. J Biol Chem, 1996 Feb 16. PMID 8632014

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing ISO
Inferred from Sequence Orthology
more info
  
involved_in viral protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal peptidase complex subunit 3
Names
signal peptidase complex subunit 3 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191073.1 → NP_001178002.1  signal peptidase complex subunit 3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D3ZF12
    Related
    ENSRNOP00000062708.2, ENSRNOT00000067375.5
    Conserved Domains (1) summary
    pfam04573
    Location:4 → 173
    SPC22; Signal peptidase subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    44038421..44043855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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