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Rpl39l ribosomal protein L39-like [ Mus musculus (house mouse) ]

Gene ID: 68172, updated on 27-Nov-2024

Summary

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Official Symbol
Rpl39lprovided by MGI
Official Full Name
ribosomal protein L39-likeprovided by MGI
Primary source
MGI:MGI:1915422
See related
Ensembl:ENSMUSG00000039209 AllianceGenome:MGI:1915422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930517K11Rik
Summary
A structural constituent of ribosome. Involved in cytoplasmic translation and spermatogenesis. Part of cytosolic large ribosomal subunit. Is expressed in 2-cell stage embryo; 4-cell stage embryo; forelimb; and humerus cartilage condensation. Orthologous to human RPL39L (ribosomal protein L39 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 100.6) See more
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Genomic context

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See Rpl39l in Genome Data Viewer
Location:
16 A1; 16 5.49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (9988061..9992775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10170197..10174911)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_40070 Neighboring gene STARR-seq mESC enhancer starr_40071 Neighboring gene STARR-seq mESC enhancer starr_40072 Neighboring gene STARR-seq mESC enhancer starr_40073 Neighboring gene activating transcription factor 7 interacting protein 2 Neighboring gene STARR-seq mESC enhancer starr_40074 Neighboring gene STARR-seq mESC enhancer starr_40076 Neighboring gene predicted gene, 24667 Neighboring gene epithelial membrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis. Zou Q, et al. iScience, 2021 Dec 17. PMID 34825148, Free PMC Article
  2. Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains. Banerjee A, et al. Nucleic Acids Res, 2024 Aug 27. PMID 39041433, Free PMC Article
  3. Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity. Zou Q, et al. Int J Biochem Cell Biol, 2021 Oct. PMID 34428590
  4. RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors. Wong QW, et al. RNA Biol, 2014. PMID 24452241, Free PMC Article
  5. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity.
    Title: Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity.
  2. Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains.
    Title: Ribosomal protein RPL39L is an efficiency factor in the cotranslational folding of a subset of proteins with alpha helical domains.
  3. Results show the RP paralog Rpl39l is highly expressed in Embryonic Stem Cells and its expression strongly correlates with hepatocellular carcinoma tumor (HCC) samples with high tumor grading and alpha-fetoprotein level giving it diagnostic potential.
    Title: RPL39L is an example of a recently evolved ribosomal protein paralog that shows highly specific tissue expression patterns and is upregulated in ESCs and HCC tumors.
  4. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
    Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL39-like
Names
60S ribosomal protein L39-like
ribosomal protein L39-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026594.2 → NP_080870.1  large ribosomal subunit protein eL39-like

    See identical proteins and their annotated locations for NP_080870.1

    Status: VALIDATED

    Source sequence(s)
    AK019681
    Consensus CDS
    CCDS37248.1
    UniProtKB/Swiss-Prot
    Q9CQD0
    Related
    ENSMUSP00000041794.6, ENSMUST00000044103.6
    Conserved Domains (1) summary
    pfam00832
    Location:9 → 50
    Ribosomal_L39; Ribosomal L39 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    9988061..9992775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522506.4 → XP_006522569.1  large ribosomal subunit protein eL39-like isoform X1

    See identical proteins and their annotated locations for XP_006522569.1

    UniProtKB/Swiss-Prot
    Q9CQD0
    Related
    ENSMUSP00000112791.2, ENSMUST00000121292.8
    Conserved Domains (1) summary
    pfam00832
    Location:9 → 50
    Ribosomal_L39; Ribosomal L39 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQD0.1 GenPept UniProtKB/Swiss-Prot:Q9CQD0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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