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Reep2 receptor accessory protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 682105, updated on 27-Nov-2024

Summary

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Official Symbol
Reep2provided by RGD
Official Full Name
receptor accessory protein 2provided by RGD
Primary source
RGD:1586980
See related
EnsemblRapid:ENSRNOG00000049629 AllianceGenome:RGD:1586980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable taste receptor binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and regulation of intracellular transport. Predicted to act upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Predicted to be located in cytoplasmic microtubule; endoplasmic reticulum membrane; and plasma membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 204.2), Testes (RPKM 161.7) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Reep2 in Genome Data Viewer
Location:
18p12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26712236..26721275)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26438130..26447165)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27632562..27641594)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348765 Neighboring gene family with sequence similarity 53, member C Neighboring gene lysine demethylase 3B Neighboring gene early growth response 1 Neighboring gene 5S ribosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia. Esteves T, et al. Am J Hum Genet, 2014 Feb 6. PMID 24388663, Free PMC Article
  2. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
  3. REEP2 enhances sweet receptor function by recruitment to lipid rafts. Ilegems E, et al. J Neurosci, 2010 Oct 13. PMID 20943918, Free PMC Article
  4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport into membrane raft ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of bitter taste ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within sensory perception of sweet taste ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048047.1 → NP_001041512.1  receptor expression-enhancing protein 2

    See identical proteins and their annotated locations for NP_001041512.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105630
    UniProtKB/TrEMBL
    A0A0G2K1L5, M0R8C1, Q0VGJ9
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    26712236..26721275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277589.1 → XP_063133659.1  receptor expression-enhancing protein 2 isoform X3

  2. XM_039097126.2 → XP_038953054.1  receptor expression-enhancing protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K1L5
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  3. XM_039097125.2 → XP_038953053.1  receptor expression-enhancing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1L5
    Conserved Domains (1) summary
    pfam03134
    Location:56 → 131
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  4. XM_039097124.2 → XP_038953052.1  receptor expression-enhancing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K1L5
    Related
    ENSRNOP00000071891.2, ENSRNOT00000078969.3
    Conserved Domains (1) summary
    pfam03134
    Location:56 → 131
    TB2_DP1_HVA22; TB2/DP1, HVA22 family
Nucleotide Protein Strain
Heading Accession and Version

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