Gsto2 glutathione S-transferase omega 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsto2provided by MGI
Official Full Name: glutathione S-transferase omega 2provided by MGI
Primary source: MGI:MGI:1915464
See related: Ensembl:ENSMUSG00000025069 AllianceGenome:MGI:1915464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GSTO 2-2; 1700020F09Rik; 4930425C18Rik
Summary: Predicted to enable glutathione dehydrogenase (ascorbate) activity; glutathione transferase activity; and identical protein binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; cellular response to arsenic-containing substance; and glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 98.1) See more
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Genomic context

Location:: 19 D1; 19 40.41 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47853879..47874747)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47865438..47886308)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.
Title: Pivotal Role of GSTO2 in Ferroptotic Neuronal Injury After Intracerebral Hemorrhage.
Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in micedagger.
Title: Sperm-borne glutathione-S-transferase omega 2 accelerates the nuclear decondensation of spermatozoa during fertilization in mice†.
GSTO2 is transported and deposited in the postacrosomal sheath (PAS) region by the manchette, and that the late assembly of GSTO2 and its localization in the PAS suggests a role in regulating the oxidative and reductive state of covalently linked spermatid/sperm proteins, especially during the disassembly of the sperm accessory structures after fertilization
Title: The developmental origin and compartmentalization of glutathione-s-transferase omega 2 isoforms in the perinuclear theca of eutherian spermatozoa.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

Gsto2 (e-PCR), detects polymorphism
- UniSTS:527380

RH136264 (e-PCR)
- UniSTS:210257

U80819 (e-PCR)
- UniSTS:160858

RH125650 (e-PCR)
- UniSTS:162436

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione dehydrogenase (ascorbate) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione dehydrogenase (ascorbate) activity	ISO Inferred from Sequence Orthology more info
enables glutathione dehydrogenase (ascorbate) activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables methylarsonate reductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-ascorbic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-ascorbic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to arsenic-containing substance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to arsenic-containing substance	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase omega-2

Names: GSTO-2; MMA(V) reductase; glutathione S-transferase omega 2-2; glutathione-dependent dehydroascorbate reductase; monomethylarsonic acid reductase

NP_080895.2

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NP_084327.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

XP_030106922.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

XP_030106923.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

XP_030106924.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

XP_036017568.1

EC 1.20.4.2

EC 1.8.5.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026619.2 → NP_080895.2 glutathione S-transferase omega-2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK018953, AK075753, AK077086

Consensus CDS

CCDS29894.1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Related

ENSMUSP00000052592.5, ENSMUST00000056159.11

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
NM_030051.1 → NP_084327.1 glutathione S-transferase omega-2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK077086

Consensus CDS

CCDS29894.1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Related

ENSMUSP00000113409.2, ENSMUST00000120645.8

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

47853879..47874747

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030251062.2 → XP_030106922.1 glutathione S-transferase omega-2 isoform X1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
XM_030251064.2 → XP_030106924.1 glutathione S-transferase omega-2 isoform X1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
XM_030251063.1 → XP_030106923.1 glutathione S-transferase omega-2 isoform X1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
XM_036161675.1 → XP_036017568.1 glutathione S-transferase omega-2 isoform X1

UniProtKB/Swiss-Prot

Q8K2Q2

UniProtKB/TrEMBL

Q8BW12, Q9D2S1

Conserved Domains (2) summary

cd03184
Location:108 → 230

GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases

cd03055
Location:6 → 94

GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...