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Pirb paired Ig-like receptor B [ Rattus norvegicus (Norway rat) ]

Gene ID: 683463, updated on 4-Jan-2025

Summary

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Symbol
Pirbprovided by RGD
Full Name
paired Ig-like receptor Bprovided by RGD
Primary source
RGD:1589827
See related
EnsemblRapid:ENSRNOG00000058422 AllianceGenome:RGD:1589827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pir-A1; Lilrb3a; Lilrb3b; Lilrb3l
Summary
Predicted to enable amyloid-beta binding activity; inhibitory MHC class I receptor activity; and protein homodimerization activity. Predicted to be involved in several processes, including learning or memory; negative regulation of osteoclast differentiation; and regulation of synaptic plasticity. Predicted to act upstream of or within B cell homeostasis; B cell mediated immunity; and myeloid dendritic cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 167.8), Lung (RPKM 101.8) and 8 other tissues See more
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Genomic context

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See Pirb in Genome Data Viewer
Location:
1q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (74414556..74433015)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (65499195..65506666)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (64005797..64013268)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene paired-Ig-like receptor A2 Neighboring gene constitutive coactivator of PPAR-gamma-like protein 1 Neighboring gene leukocyte immunoglobulin like receptor B1 Neighboring gene ribosomal protein S9 Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene transmembrane channel-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. Cao W, et al. J Exp Med, 2006 Jun 12. PMID 16735691, Free PMC Article
  2. Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B(-/-) mice. Ujike A, et al. Nat Immunol, 2002 Jun. PMID 12021780
  3. Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development. Mori Y, et al. J Immunol, 2008 Oct 1. PMID 18802077
  4. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Kim T, et al. Science, 2013 Sep 20. PMID 24052308, Free PMC Article
  5. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within B cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 3A
Names
Leukocyte immunoglobulin-like receptor subfamily B member 3A
Leukocyte immunoglobulin-like receptor subfamily B member 3B
leukocyte immunoglobulin-like receptor subfamily B member 3-like
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3A
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313924.1 → NP_001300853.1  leukocyte immunoglobulin-like receptor subfamily B member 3A precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    C0HJX2, C0HJX3
    UniProtKB/TrEMBL
    A0A0G2K607
    Related
    ENSRNOP00000075528.3, ENSRNOT00000078512.3
    Conserved Domains (3) summary
    cd00096
    Location:339 → 343
    Ig; Ig strand B [structural motif]
    cd16843
    Location:225 → 314
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:325 → 417
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    74414556..74433015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273797.1 → XP_063129867.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X6

  2. XM_006228068.5 → XP_006228130.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X3

    Conserved Domains (2) summary
    smart00410
    Location:527 → 614
    IG_like; Immunoglobulin like
    cl11960
    Location:325 → 417
    Ig; Immunoglobulin domain

  3. XM_001076302.8 → XP_001076302.3  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X1

    Conserved Domains (2) summary
    smart00410
    Location:527 → 614
    IG_like; Immunoglobulin like
    cl11960
    Location:325 → 417
    Ig; Immunoglobulin domain

  4. XM_006228067.5 → XP_006228129.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X2

    Conserved Domains (2) summary
    smart00410
    Location:488 → 575
    IG_like; Immunoglobulin like
    cl11960
    Location:325 → 417
    Ig; Immunoglobulin domain

  5. XM_006228069.5 → XP_006228131.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X4

    Conserved Domains (2) summary
    smart00410
    Location:462 → 549
    IG_like; Immunoglobulin like
    cl11960
    Location:260 → 352
    Ig; Immunoglobulin domain

  6. XM_006228070.5 → XP_006228132.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X5

    Conserved Domains (2) summary
    smart00410
    Location:432 → 519
    IG_like; Immunoglobulin like
    cl11960
    Location:230 → 322
    Ig; Immunoglobulin domain

  7. XM_063273801.1 → XP_063129871.1  leukocyte immunoglobulin-like receptor subfamily B member 3A isoform X7

RNA

  1. XR_010057604.1 RNA Sequence

  2. XR_010057608.1 RNA Sequence

  3. XR_010057612.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0G2KBC9.1 GenPept UniProtKB/Swiss-Prot:A0A0G2KBC9
C0HJX2.1 GenPept UniProtKB/Swiss-Prot:C0HJX2
C0HJX3.1 GenPept UniProtKB/Swiss-Prot:C0HJX3

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