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Ppp1r42 protein phosphatase 1, regulatory subunit 42 [ Rattus norvegicus (Norway rat) ]

Gene ID: 683514, updated on 4-Jan-2025

Summary

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Official Symbol
Ppp1r42provided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 42provided by RGD
Primary source
RGD:1585679
See related
EnsemblRapid:ENSRNOG00000006804 AllianceGenome:RGD:1585679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity; dynein complex binding activity; and tubulin binding activity. Predicted to be involved in regulation of phosphatase activity. Predicted to be located in centrosome and manchette. Orthologous to human PPP1R42 (protein phosphatase 1 regulatory subunit 42). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Testes (RPKM 111.5), Lung (RPKM 10.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r42 in Genome Data Viewer
Location:
5q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14009972..14057330)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9227109..9274461)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8911356..8956313)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene COP9 signalosome subunit 5 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene uncharacterized LOC102556004 Neighboring gene transcription factor 24 Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice. Wang R, et al. PLoS One, 2011. PMID 21738792, Free PMC Article
  2. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
  3. TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Wang R, et al. Biol Cell, 2010 Jan 13. PMID 19886865, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in manchette ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule organizing center ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127569.2 → NP_001121041.1  protein phosphatase 1 regulatory subunit 42

    See identical proteins and their annotated locations for NP_001121041.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y8A7, B1WBU1, E9PTW7
    Related
    ENSRNOP00000061242.2, ENSRNOT00000066395.4
    Conserved Domains (2) summary
    sd00033
    Location:30 → 51
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:27 → 246
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    14009972..14057330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288419.1 → XP_063144489.1  protein phosphatase 1 regulatory subunit 42 isoform X1

  2. XM_039110784.2 → XP_038966712.1  protein phosphatase 1 regulatory subunit 42 isoform X2

    Conserved Domains (1) summary
    cd21340
    Location:2 → 81
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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