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Aspdh aspartate dehydrogenase domain containing [ Mus musculus (house mouse) ]

Gene ID: 68352, updated on 27-Nov-2024

Summary

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Official Symbol
Aspdhprovided by MGI
Official Full Name
aspartate dehydrogenase domain containingprovided by MGI
Primary source
MGI:MGI:1915602
See related
Ensembl:ENSMUSG00000038704 AllianceGenome:MGI:1915602
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012D14Rik
Summary
Predicted to enable NADP binding activity and aspartate dehydrogenase activity. Predicted to be involved in NAD biosynthetic process. Orthologous to human ASPDH (aspartate dehydrogenase domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 186.3), kidney adult (RPKM 84.0) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Aspdh in Genome Data Viewer
Location:
7 B3; 7 28.83 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44114859..44117175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44465435..44467751)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39002 Neighboring gene leucine rich repeat containing 4B Neighboring gene predicted gene, 39003 Neighboring gene STARR-positive B cell enhancer ABC_E9110 Neighboring gene Josephin domain containing 2 Neighboring gene microRNA 7052 Neighboring gene RIKEN cDNA 5430431A17 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
aspartate dehydrogenase domain-containing protein
Names
putative L-aspartate dehydrogenase
NP_080966.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026690.1 → NP_080966.1  aspartate dehydrogenase domain-containing protein

    See identical proteins and their annotated locations for NP_080966.1

    Status: PROVISIONAL

    Source sequence(s)
    AK002587
    Consensus CDS
    CCDS21207.1
    UniProtKB/Swiss-Prot
    Q8VCQ0, Q9DCQ2
    UniProtKB/TrEMBL
    D3Z253
    Related
    ENSMUSP00000039202.5, ENSMUST00000035929.11
    Conserved Domains (2) summary
    pfam01958
    Location:176 → 265
    DUF108; Domain of unknown function DUF108
    pfam03447
    Location:17 → 127
    NAD_binding_3; Homoserine dehydrogenase, NAD binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44114859..44117175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCQ2.1 GenPept UniProtKB/Swiss-Prot:Q9DCQ2

Gene LinkOut

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