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Pbld1 phenazine biosynthesis-like protein domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 68371, updated on 27-Nov-2024

Summary

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Official Symbol
Pbld1provided by MGI
Official Full Name
phenazine biosynthesis-like protein domain containing 1provided by MGI
Primary source
MGI:MGI:1915621
See related
Ensembl:ENSMUSG00000112129 AllianceGenome:MGI:1915621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pbld; Mawbp; 0610038K03Rik
Summary
Predicted to enable identical protein binding activity and isomerase activity. Predicted to be involved in maintenance of gastrointestinal epithelium. Predicted to act upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in eye; heart; liver; metanephros; and retina. Orthologous to human PBLD (phenazine biosynthesis like protein domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 53.4), kidney adult (RPKM 47.4) and 3 other tissues See more
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Genomic context

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See Pbld1 in Genome Data Viewer
Location:
10 B4; 10 32.53 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62896404..62913743)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63060625..63077964)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain-containing 2 Neighboring gene STARR-seq mESC enhancer starr_26916 Neighboring gene heterogeneous nuclear ribonucleoprotein H3 Neighboring gene phenazine biosynthesis-like protein domain containing 2 Neighboring gene predicted gene 16143 Neighboring gene STARR-seq mESC enhancer starr_26919 Neighboring gene atonal bHLH transcription factor 7 Neighboring gene myopalladin Neighboring gene STARR-seq mESC enhancer starr_26921 Neighboring gene STARR-seq mESC enhancer starr_26922 Neighboring gene STARR-seq mESC enhancer starr_26924

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of a remote enhancer near ATOH7 disrupts retinal neurogenesis, causing NCRNA disease. Ghiasvand NM, et al. Nat Neurosci, 2011 May. PMID 21441919, Free PMC Article
  2. Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits. Platt RJ, et al. Cell Rep, 2017 Apr 11. PMID 28402856, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of gastrointestinal epithelium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within_positive_effect negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phenazine biosynthesis-like domain-containing protein 1
Names
MAWD binding protein homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359529.1 → NP_001346458.1  phenazine biosynthesis-like domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113107, AK143947
    Consensus CDS
    CCDS23895.1
    UniProtKB/Swiss-Prot
    Q8VCF3, Q9DCG6
    UniProtKB/TrEMBL
    K3W4L7
    Conserved Domains (1) summary
    cl27516
    Location:9 → 284
    PhzC-PhzF; Phenazine biosynthesis-like protein

  2. NM_026701.3 → NP_080977.2  phenazine biosynthesis-like domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080977.2

    Status: VALIDATED

    Source sequence(s)
    AC113107, AK143947
    Consensus CDS
    CCDS23895.1
    UniProtKB/Swiss-Prot
    Q8VCF3, Q9DCG6
    UniProtKB/TrEMBL
    K3W4L7
    Related
    ENSMUSP00000136589.2, ENSMUST00000178684.3
    Conserved Domains (1) summary
    cl27516
    Location:9 → 284
    PhzC-PhzF; Phenazine biosynthesis-like protein

RNA

  1. NR_153192.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113107, BC028493, BE628967
    Related
    ENSMUST00000219687.2

  2. NR_153193.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113107, BC028493
    Related
    ENSMUST00000219045.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    62896404..62913743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514030.4 → XP_006514093.1  phenazine biosynthesis-like domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    cl29427
    Location:74 → 285
    PhzC-PhzF; Phenazine biosynthesis-like protein

  2. XM_006514029.4 → XP_006514092.1  phenazine biosynthesis-like domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    K3W4L7
    Conserved Domains (1) summary
    cl29427
    Location:74 → 349
    PhzC-PhzF; Phenazine biosynthesis-like protein

  3. XM_006514031.1 → XP_006514094.1  phenazine biosynthesis-like domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    K3W4L7
    Conserved Domains (1) summary
    cl29427
    Location:41 → 316
    PhzC-PhzF; Phenazine biosynthesis-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCG6.2 GenPept UniProtKB/Swiss-Prot:Q9DCG6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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